Synthesis of some new heterocyclic compounds from available nitriles with expected biological activity / Salwa Magdy Ahmed Eldaly ; Sypervised Fathy M. Abdelrazek

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The original work of this thesis includes the study of the reaction of 1- cyanoacetylpyrazole 1 with phenyl isothiocyanate followed by the addition of different halocarbonyl compounds to afford thiazole and oxathiepine derivatives and the reaction of the arylhydrazo derivative of this compound with phenylene-1,4-diamine to give the compounds 13. Refluxing of 13 with hydrazine hydrate afforded aminotriazoles 15. Compound 1 reacts with different arylazo derivatives of aminopyrazoles to afford the corresponding pyrazolo[1,5-a]pyrimidine derivatives. Compound 21 reacted with phenyl isothiocyanate followed by the addition of different halocarbonyl compounds, the N-alkylated derivatives 24 were obtained.The reaction of 1 with 4- aminoacetophenone afforded the cyanoacetamide derivative 26 which underwent different chemical reactions to give arylidines, iminochromenes, di-arylidenes, di- iminochromenes, di-arylazo compounds and di-thiazoles. The antitumor activity of some of the newly synthesized compounds was investigated in vitro besides Molecule rmodeling (using MOE 2008)

Issued also as CD