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Single nucleotide polymorphism (SNP) rs8099917 as a predictive factor of virological response to pegylated interferon plus ribavirin in treatment of chronic hepatitis C virus patients / Ahmed Mohamed Eldeeb ; Supervised Gamal Eldin Esmat , Wahid Halim Doss , Mohamed Ali Saber

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Mohamed Eldeeb , 2014Description: 155 P. : charts ; 25cmOther title:
  • استخدام النيكوليوتيد الفردى متعدد الأشكال (رس8099917) كوسيلة تنبؤية للاستجابة للانترفيرون طويل المفعول و الريبافيرين فى علاج مرضى فيروس سى الكبدى المزمن [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Introduction: For SNP rs8099917, the favorable T allele is associated with a higher SVR after PEG - IFN alpha/RBV therapy while the G allele is a risk factor for non - response. Aim of work: Is to assess the value of (SNP) rs8099917 as a predictor of SVR. Methods: This study is a retrospective controlled study and was performed on a total number of 240 patients who were treated by PEG - IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: Determination of (SNP) rs8099917 before starting antiviral therapy may thus serve as a good response predictor
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2014.Ah.S (Browse shelf(Opens below)) Not for loan 01010110064251000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2014.Ah.S (Browse shelf(Opens below)) 64251.CD Not for loan 01020110064251000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Introduction: For SNP rs8099917, the favorable T allele is associated with a higher SVR after PEG - IFN alpha/RBV therapy while the G allele is a risk factor for non - response. Aim of work: Is to assess the value of (SNP) rs8099917 as a predictor of SVR. Methods: This study is a retrospective controlled study and was performed on a total number of 240 patients who were treated by PEG - IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: Determination of (SNP) rs8099917 before starting antiviral therapy may thus serve as a good response predictor

Issued also as CD

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