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Design and synthesis of some rimonabant congeners of anticipated pharmacological activity as cannabinoid receptor modulators / Essam Eldin Abdelfattah Osman ; Supervised Samir M. Elmoghazy , Mohamed M. Hussein , Sahar Mahmoud AbouSeri

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Essam Eldin Abdelfattah Osman , 2014Description: 216 P. : photographs ; 25cmOther title:
  • تصميم و تشييد بعض مشابهات الريمونابانت من المتوقع أن يكون لها فاعلية أقربازينية على مستقبلات الكانابينويد [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: In this thesis, novel series of cannabinoid receptor modulators were designed. Molecular modeling techniques were used to support the design. Semicarbazone derivatives IIIa-d and thiosemicarbazone IVa- d, Va and Vb and VIIa- e, triazole derivatives XIIIa- q, XIV and XVa and XVb and furan- 3- carbonitrile derivatives XVIIIa- i, XXa- i and XXIIa- c were synthesized. Seventeen target compounds were evaluated in an in vitro functional assay for their agonist and antagonist activities at hCB1 and hCB2 receptors. Fourteen target compounds were evaluated in an affinity binding assay in vitro towards CB1 and CB2 receptors. Compounds IIIb and IVb were CB2 agonists while IIId and IVd were CB2 antagonists. Triazole derivatives XIII were active as CB1 antagonists. Furan -3- carbonitrile XVIII and XX were variably binding to both receptor subtypes
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2014.Es.D (Browse shelf(Opens below)) Not for loan 01010110064583000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2014.Es.D (Browse shelf(Opens below)) 64583.CD Not for loan 01020110064583000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

In this thesis, novel series of cannabinoid receptor modulators were designed. Molecular modeling techniques were used to support the design. Semicarbazone derivatives IIIa-d and thiosemicarbazone IVa- d, Va and Vb and VIIa- e, triazole derivatives XIIIa- q, XIV and XVa and XVb and furan- 3- carbonitrile derivatives XVIIIa- i, XXa- i and XXIIa- c were synthesized. Seventeen target compounds were evaluated in an in vitro functional assay for their agonist and antagonist activities at hCB1 and hCB2 receptors. Fourteen target compounds were evaluated in an affinity binding assay in vitro towards CB1 and CB2 receptors. Compounds IIIb and IVb were CB2 agonists while IIId and IVd were CB2 antagonists. Triazole derivatives XIII were active as CB1 antagonists. Furan -3- carbonitrile XVIII and XX were variably binding to both receptor subtypes

Issued also as CD

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