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The possible protective effect of certain natural products in experimentally induced nephrotoxicity in rats / Maha Moussa Mahmoud Shouman ; Supervised Sanaa A. Kenawy , Amany I. Elbrairy , Rania M. Abdelsalam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maha Moussa Mahmoud Shouman , 2014Description: 159 P. : charts , photographs ; 25cmOther title:
  • إمكانية التأثير الوقائى لبعض المنتجات الطبيعية فى التسمم الكلوى المحدث تجريبيا فى الجرذان [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that inflammation and oxidative stress may contribute to the pathogenesis of cisplatin induced acute renal failure. A large number of natural products and dietary components have been evaluated as potential chemoprotective agents. The present study was performed to explore the effect of pretreatment with curcumin (60 mg / kg) and grape seed extract (200 mg / kg) either alone or in combination with valsartan (30 mg / kg) in cisplatin induced nephrotoxicity in rats. Blood samples were collected to measure renal function tests including serum level of creatinine (Cr) and blood urea nitrogen (BUN) as well as serum level of c- reactive protein (CRP), tumor necrosis factor alpha (TNF- Ü) and interleukin 10 (IL - 10). Furthermore, kidneys were excised for histological examination and for the measurement of oxidative stress biomarkers including renal contents of malondialdehyde MDA
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ma.P (Browse shelf(Opens below)) Not for loan 01010110064589000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ma.P (Browse shelf(Opens below)) 64589.CD Not for loan 01020110064589000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that inflammation and oxidative stress may contribute to the pathogenesis of cisplatin induced acute renal failure. A large number of natural products and dietary components have been evaluated as potential chemoprotective agents. The present study was performed to explore the effect of pretreatment with curcumin (60 mg / kg) and grape seed extract (200 mg / kg) either alone or in combination with valsartan (30 mg / kg) in cisplatin induced nephrotoxicity in rats. Blood samples were collected to measure renal function tests including serum level of creatinine (Cr) and blood urea nitrogen (BUN) as well as serum level of c- reactive protein (CRP), tumor necrosis factor alpha (TNF- Ü) and interleukin 10 (IL - 10). Furthermore, kidneys were excised for histological examination and for the measurement of oxidative stress biomarkers including renal contents of malondialdehyde MDA

Issued also as CD

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