Assessment of global human DNA - methylation methylenetetrahydrofolate reductase (MTHFR) genetic variants and their role in the development of neural tube defects NTDs / Asmaa Fawzi Abdelaleem Moustafa ; Supervised Amr Saad Mohammed , Alice kamal Abdelaleem , Mohamed Mohamed Mohi Eldin

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Asmaa Fawzi Abdelaleem Moustafa

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TextLanguage: English Publication details: Cairo : Asmaa Fawzi Abdelaleem Moustafa , 2014Description: 115 P. : photographs ; 25cmOther title:

التقييم الكلى لإضافة مجموعة الميثيل للحمض النووى الدى أوكسى ريبوزى و الإختلافات الجينية فى الميثيلين تتراهيدرو فولات ريدكتاز و دورهم فى حدوث عيوب القناة العصبية [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Neural tube defects (NTD) are severe, common birth defects that are caused by partial or complete failure of neural tube closure. Our aim of work is to investigate the role of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and global DNA methylation status as factors involved in NTDs etiology. A hospital based case-control study was performed. Our results showed a significant hypomethylation in NTDs subjects versus control. Direct association between the frequency of 677TT genotype of the MTHFR gene and NTDs has not been demonstrated in our study

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2014.As.A (Browse shelf(Opens below))		Not for loan	01010110064752000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2014.As.A (Browse shelf(Opens below))	64752.CD	Not for loan	01020110064752000

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Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry

Neural tube defects (NTD) are severe, common birth defects that are caused by partial or complete failure of neural tube closure. Our aim of work is to investigate the role of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and global DNA methylation status as factors involved in NTDs etiology. A hospital based case-control study was performed. Our results showed a significant hypomethylation in NTDs subjects versus control. Direct association between the frequency of 677TT genotype of the MTHFR gene and NTDs has not been demonstrated in our study

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