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Desensitization of donor specific resistant positive lymphocyte cross-match by donor specific mesenchymal stem cell transfusion / Ahmed Atef Fouad Mekky ; Supervised Mohammed Gamal Aldin Saadi , May Abdelmonem Hasab Allah , Mervat Mohammed Saad Elansary

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Atef Fouad Mekky , 2014Description: 138 P. : charts , facsimiles ; 25cmOther title:
  • إزالة التحسس بإنهاء التفاعل التطابقى الإيجابى للخلايا الليمفاوية بخلايا المتبرع الجزعية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Background: Donor specific antibodies (DSA) and a positive cross-match in patients who are sensitized through previous blood transfusions, organ transplantation or pregnancy are an important obstacle in kidney transplantation. , trials of allograft transplantation across the HLA barrier have employed desensitization strategies, including the use of plasmapheresis, intravenous immunoglobulins, anti-B-cell monoclonal antibodies and splenectomy, associated with high-intensity immunosuppressive regimens. These measures have proven only partially successful in preventing or treating humoral rejection in high-risk patients, while causing a significant increase in the risk of severe infectious complications occurring after transplantation. Mesenchymal stem cells (MSCs) have immunomodulatory capacity and are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients. Aim of the Work: To evaluate the effect of mesenchymal stem cell transfusion on desensitization of donor specific resistant positive lymphocyte cross-match and /or high titre Panel Reactive Antibody (PRA)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2014.Ah.D (Browse shelf(Opens below)) Not for loan 01010110065050000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2014.Ah.D (Browse shelf(Opens below)) 65050.CD Not for loan 01020110065050000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Donor specific antibodies (DSA) and a positive cross-match in patients who are sensitized through previous blood transfusions, organ transplantation or pregnancy are an important obstacle in kidney transplantation. , trials of allograft transplantation across the HLA barrier have employed desensitization strategies, including the use of plasmapheresis, intravenous immunoglobulins, anti-B-cell monoclonal antibodies and splenectomy, associated with high-intensity immunosuppressive regimens. These measures have proven only partially successful in preventing or treating humoral rejection in high-risk patients, while causing a significant increase in the risk of severe infectious complications occurring after transplantation. Mesenchymal stem cells (MSCs) have immunomodulatory capacity and are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients. Aim of the Work: To evaluate the effect of mesenchymal stem cell transfusion on desensitization of donor specific resistant positive lymphocyte cross-match and /or high titre Panel Reactive Antibody (PRA)

Issued also as CD

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