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Association between MMP-9, MMP-3 polymorphisms and risk of myocardial infarction / Baher Emil Ibrahim ; Supervised Manal Michel Wilson , Ashraf Wadie Andraos , Nadia Ibrahim Swelem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Baher Emil Ibrahim , 2014Description: 94 P. : charts ; 25cmOther title:
  • دراسة الرابطة بين الأشكال المتعددة من مصفوفة ميتالوبروتينيس {u٠٦ئ٩}و{u٠٦ئ٣} و خطر احتشاء عضلة القلب في المرضى المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Myocardial infarction is caused by several inherited and acquired risk factors that predispose to the development of atherosclerotic lesions and plaque rupture.This rupture of an atherosclerotic plaque is a major event in the pathogenesis of an acute myocardial infarction (AMI). MMP-9 (gelatinase B) might play an important role in matrix degradation and the subsequent rupture of the atherosclerotic plaques. A functional single nucleotide polymorphism in the MMP-9 promoter, with a cytosine to thymidine transition at position -1562, was found. The T allele had a higher promoter activity than the C allele, and was associated with an elevation in both the levels of MMP-9 expression level and serum MMP-9 in humans and an association of a SNP in the MMP-9 promoter with coronary artery disease and risk of myocardial infarction lesions
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ba.A (Browse shelf(Opens below)) Not for loan 01010110065357000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ba.A (Browse shelf(Opens below)) 65357.CD Not for loan 01020110065357000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Myocardial infarction is caused by several inherited and acquired risk factors that predispose to the development of atherosclerotic lesions and plaque rupture.This rupture of an atherosclerotic plaque is a major event in the pathogenesis of an acute myocardial infarction (AMI). MMP-9 (gelatinase B) might play an important role in matrix degradation and the subsequent rupture of the atherosclerotic plaques. A functional single nucleotide polymorphism in the MMP-9 promoter, with a cytosine to thymidine transition at position -1562, was found. The T allele had a higher promoter activity than the C allele, and was associated with an elevation in both the levels of MMP-9 expression level and serum MMP-9 in humans and an association of a SNP in the MMP-9 promoter with coronary artery disease and risk of myocardial infarction lesions

Issued also as CD

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