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The role of dexmedetomidine in decreasing acute kidney injury in children with acyanotic heart disease undergoing total correction by a new urinary biomarker kidney injury molecule-1 / Sarah Abdelsalam Elmetwally Kasem ; Supervised Azza Mohamed Ezzat , Wafaa Mohamed Alsadek , Olfat Gamil Shaker

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sarah Abdelsalam Elmetwally Kasem , 2014Description: 132 Leaves : charts , facsimiles ; 25cmOther title:
  • دور عقار الدكسميدتوميدين في تقليل الإصابة الكلوية الحادة عند الأطفال المصابين بأمراض القلب اللازرقية الذين يخضعون للتصحيح الكامل بإستخدام الدلالة البولية الحديثة "كيم -1" [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: Cardiac surgery with cardiopulmonary bypass (CPB) is the most frequent major surgical procedure worldwide. Acute kidney injury (AKI) is a common and serious complication encountered in 30{u2013}40% after CPB. Once AKI is established, there is no effective treatment for human AKI, and dialysis merely provides supportive care. There in lies the Achilles{u2019} heel of AKI management ; the paucity of early biomarkers has lead to an unacceptable delay in initiating therapy in humans.Serum creatinine is insensitive for the early detection of AKI. KIM-1 is one of the most highly induced proteins in the kidney after AKI in animal models, and a proteolytically processed domain of KIM-1 is easily detected in the urine soon after AKI. In a small human cross-sectional study, KIM-1 expression was markedly induced in proximal tubules in kidney biopsies from patients with established AKI (primarily ischemic), and urinary KIM-1 measured by ELISA distinguished ischemic AKI from prerenal azotemia and chronic renal disease
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2014.Sa.R (Browse shelf(Opens below)) Not for loan 01010110065354000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2014.Sa.R (Browse shelf(Opens below)) 65354.CD Not for loan 01020110065354000
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Cai01.11.01.Ph.D.2014.Sa.I Intra-articular or intravenous magnesium sulphate as an adjuvant to femoral nerve block for postoperative analgesia in arthroscopic anterior cruciate ligament reconstruction / Cai01.11.01.Ph.D.2014.Sa.I Intra-articular or intravenous magnesium sulphate as an adjuvant to femoral nerve block for postoperative analgesia in arthroscopic anterior cruciate ligament reconstruction / Cai01.11.01.Ph.D.2014.Sa.R The role of dexmedetomidine in decreasing acute kidney injury in children with acyanotic heart disease undergoing total correction by a new urinary biomarker kidney injury molecule-1 / Cai01.11.01.Ph.D.2014.Sa.R The role of dexmedetomidine in decreasing acute kidney injury in children with acyanotic heart disease undergoing total correction by a new urinary biomarker kidney injury molecule-1 / Cai01.11.01.Ph.D.2014.Sh.P Peri - operative complications of endoscopic upper airway laser surgery in Kasr Alainy Hospital : A prospective study / Cai01.11.01.Ph.D.2014.Sh.P Peri - operative complications of endoscopic upper airway laser surgery in Kasr Alainy Hospital : A prospective study / Cai01.11.01.Ph.D.2014.We.C Clinical evaluation of continuous spinal anesthesia compared to epidural anesthesia in mild to moderate preeclamptic patients undergoing cesarean section /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Cardiac surgery with cardiopulmonary bypass (CPB) is the most frequent major surgical procedure worldwide. Acute kidney injury (AKI) is a common and serious complication encountered in 30{u2013}40% after CPB. Once AKI is established, there is no effective treatment for human AKI, and dialysis merely provides supportive care. There in lies the Achilles{u2019} heel of AKI management ; the paucity of early biomarkers has lead to an unacceptable delay in initiating therapy in humans.Serum creatinine is insensitive for the early detection of AKI. KIM-1 is one of the most highly induced proteins in the kidney after AKI in animal models, and a proteolytically processed domain of KIM-1 is easily detected in the urine soon after AKI. In a small human cross-sectional study, KIM-1 expression was markedly induced in proximal tubules in kidney biopsies from patients with established AKI (primarily ischemic), and urinary KIM-1 measured by ELISA distinguished ischemic AKI from prerenal azotemia and chronic renal disease

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