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Markers of myofibroblast progenitor cells as predictors of HCV-induced hepatic fibrosis and carcinogenesis / Shaimaa Abdelsattar Abbas Hasan ; Supervised Inas Ismail Raafat , Mona Mohamed Kamel Zoheiry , Safa Sayed Meshaal

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaimaa Abdelsattar Abbas Hasan , 2014Description: 134 P. : charts , facsimiles ; 25cmOther title:
  • دراسة الدلالات السابحة في الدم و المرتبطة بنزوح الخلايا المكونة للخلايا الليفية العضلية إلى الكبد كمؤشر لحدوث التليف و الأورام السرطانية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Aim of the work: To analyze the impact of serum biomarkers of EMT on fibrogenic process and progression to tumorogenesis caused by HCV. Results: The serum TGF-Ý1, BMP-7, CTGF and YKL-40 were significantly increased in CHC, LC and HCC cases compared with normal controls (p <0.001). Serum TGF-Ý1/ BMP-7 ratio shows increase from F0 to F4 with no significant difference between LC and HCC. CTGF was significantly high in LC and YKL-40 was significantly high in HCC. Conclusions: Increase of TGF-Ý1/BMP-7 ratio reflects the rate of EMT. In HCV hepatic patients: the simultaneous determination of TGF-Ý1/BMP-7 ratio and of CTGF in serum might provide information on fibrogenic activity, while this ratio in association with YKL-40 can be used for monitoring of the malignant transformation.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Sh.M (Browse shelf(Opens below)) Not for loan 01010110066495000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Sh.M (Browse shelf(Opens below)) 66495.CD Not for loan 01020110066495000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Aim of the work: To analyze the impact of serum biomarkers of EMT on fibrogenic process and progression to tumorogenesis caused by HCV. Results: The serum TGF-Ý1, BMP-7, CTGF and YKL-40 were significantly increased in CHC, LC and HCC cases compared with normal controls (p <0.001). Serum TGF-Ý1/ BMP-7 ratio shows increase from F0 to F4 with no significant difference between LC and HCC. CTGF was significantly high in LC and YKL-40 was significantly high in HCC. Conclusions: Increase of TGF-Ý1/BMP-7 ratio reflects the rate of EMT. In HCV hepatic patients: the simultaneous determination of TGF-Ý1/BMP-7 ratio and of CTGF in serum might provide information on fibrogenic activity, while this ratio in association with YKL-40 can be used for monitoring of the malignant transformation.

Issued also as CD

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