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Genetic polymorphisms of TNF-alpha and IL-8 and their impact on the clinical outcome in Egyptian children with sickle cell anemia / Dalia Kamal Hegazy Abdelrahman ; Supervised Rania Mohamed Fawzy , Ilham Youssry Ibrahim , Nadia Ibrahim Sewelam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dalia Kamal Hegazy Abdelrahman , 2014Description: 142 P. : charts , facsimiles ; 25cmOther title:
  • وتأثيرها فى مرضى انيميا الخلايا المنجليةTNF-alpha and IL- 8 التغيرات الجينية فى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Sickle cell disease (SCD) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-{uF061}) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms and laboratory data in children with SCD. Results: In the present work, TNFÜ-AA genotype and the mutant A allele were higher in both groups of SCD patients compared to control group. But there was no significant difference detected between steady state and crisis patients regarding TNFÜ-AA genotype or TNFÜ-A allele. As regards IL-8; IL-8 TT genotype and mutant T allele were significantly higher in both groups of SCD patients compared to control group. There was no significant difference detected between steady state and crisis patients regarding IL-8 TT genotype or IL-8 T allele. Conclusion: From these results we can conclude that the presence of TNF-Ü ''-308 G>A" and IL-8 "-251 A>T" polymorphisms is associated with increased risk of morbidity in SCD, but is not associated with increased disease severity
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Da.G (Browse shelf(Opens below)) Not for loan 01010110066705000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Da.G (Browse shelf(Opens below)) 66705.CD Not for loan 01020110066705000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Sickle cell disease (SCD) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-{uF061}) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms and laboratory data in children with SCD. Results: In the present work, TNFÜ-AA genotype and the mutant A allele were higher in both groups of SCD patients compared to control group. But there was no significant difference detected between steady state and crisis patients regarding TNFÜ-AA genotype or TNFÜ-A allele. As regards IL-8; IL-8 TT genotype and mutant T allele were significantly higher in both groups of SCD patients compared to control group. There was no significant difference detected between steady state and crisis patients regarding IL-8 TT genotype or IL-8 T allele. Conclusion: From these results we can conclude that the presence of TNF-Ü ''-308 G>A" and IL-8 "-251 A>T" polymorphisms is associated with increased risk of morbidity in SCD, but is not associated with increased disease severity

Issued also as CD

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