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Role of cytokines genes polymorphisms in predicting the outcome of HLA matched sibling bone marrow transplantation / Abdallah Mohamed Gamil Abdallah ; Supervised Azza Mahmoud Kamel , Raafat M. Abdelfattah , Gamal Thabet Ali

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Abdallah Mohamed Gamil Abdallah , 2015Description: 228 P. : facsimiles ; 25cmOther title:
  • التنوع فى جينات المحركات الخلوية و دورها فى التنبؤ بنتيجة زرع النخاع بين الأشقاء المتماثلين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (HSCT) and cytokines are recognized as important mediators of GVHD. Polymorphisms in the regulatory regions of several cytokine genes have been associated with a number of immune diseases as well as post HSCT complications. The aim of this study was the detection of cytokines genes polymorphisms (CGPs) and their relation to post HSCT complications mainly GVHD in Egyptian patients receiving HSCT. The study included 106 patient/donor pairs who received peripheral blood stem cell transplantation (PBSCT) from HLA-matched identical siblings. DNA for cytokine genotyping was available for 105 patients and 98 donors only. Polymerase chain reaction with sequence specific primers (PCR-SSP) technique was used to analyze the following cytokines genotypes: Tumor necrosis factor-alpha (TNF-Ü) ({u2212}308), transforming growth factor beta1 (TGF-Ý1) (codon10 and codon 25), interleukin (IL)-6 ({u2212}174), IL-10 ({u2212}1082, {u2212}819 and {u2212}592) and Interferon {u2013}gamma (IFN-Þ) (+874). From the current study we can conclude that there was no impact of all tested CGPs on development of GVHD or other post HSCT complications.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2015.Ab.R (Browse shelf(Opens below)) Not for loan 01010110067282000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2015.Ab.R (Browse shelf(Opens below)) 67282.CD Not for loan 01020110067282000
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Cai01.19.03.Ph.D.2014.Ma.R Role of single nucleotide polymorphism in DNA repair genes in cytogenetic status in acute myeloid leukemia patients / Cai01.19.03.Ph.D.2014.Ma.R Role of single nucleotide polymorphism in DNA repair genes in cytogenetic status in acute myeloid leukemia patients / Cai01.19.03.Ph.D.2015.Ab.R Role of cytokines genes polymorphisms in predicting the outcome of HLA matched sibling bone marrow transplantation / Cai01.19.03.Ph.D.2015.Ab.R Role of cytokines genes polymorphisms in predicting the outcome of HLA matched sibling bone marrow transplantation / Cai01.19.03.Ph.D.2015.Em.F Fusion gene transcript levels at diagnosis and their kinetics in response to therapy as prognostic indicators in acute lymphoblastic leukemia : Part of conjoint project with St. Jude Children Cancer Research Hospital / Cai01.19.03.Ph.D.2015.Em.F Fusion gene transcript levels at diagnosis and their kinetics in response to therapy as prognostic indicators in acute lymphoblastic leukemia : Part of conjoint project with St. Jude Children Cancer Research Hospital / Cai01.19.03.Ph.D.2015.Em.R Role of GSTP1 and RAD51 gene polymorphisms in the pathogenesis of acute myeloid leukemia /

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (HSCT) and cytokines are recognized as important mediators of GVHD. Polymorphisms in the regulatory regions of several cytokine genes have been associated with a number of immune diseases as well as post HSCT complications. The aim of this study was the detection of cytokines genes polymorphisms (CGPs) and their relation to post HSCT complications mainly GVHD in Egyptian patients receiving HSCT. The study included 106 patient/donor pairs who received peripheral blood stem cell transplantation (PBSCT) from HLA-matched identical siblings. DNA for cytokine genotyping was available for 105 patients and 98 donors only. Polymerase chain reaction with sequence specific primers (PCR-SSP) technique was used to analyze the following cytokines genotypes: Tumor necrosis factor-alpha (TNF-Ü) ({u2212}308), transforming growth factor beta1 (TGF-Ý1) (codon10 and codon 25), interleukin (IL)-6 ({u2212}174), IL-10 ({u2212}1082, {u2212}819 and {u2212}592) and Interferon {u2013}gamma (IFN-Þ) (+874). From the current study we can conclude that there was no impact of all tested CGPs on development of GVHD or other post HSCT complications.

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