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Fast dissolving systems for an angiotensin receptor blocker / Shady Mohammed Abdelhalim ; Supervised Nabaweya Abdelaziz , Omaima Naim Elgazayerly , Maha Mohammed Amin

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shady Mohammed Abdelhalim , 2015Description: 267 P. : charts ; 25cmOther title:
  • أنظمة سريعة الذوبان لعقار غالق لمستقبلات الأنجيوتنسين [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: From the obtained results, it was possible to conclude the following: 1. After oral administration of Disartan capsule and LS-SNEDDS formula (A18) with dose equivalent to 30 mg Valsartan/ kg rat, the mean value of the plasma peak concentration (Cpmax) was found to be 8.26 ± 1.24 æg/ml and 14.38 ± 1.45 æg/ml respectively attained after tmax of 1.50 hr. and 0.50 hr. respectively. 2. The bioavailability of Valsartan from LS-SNEDDS relative to Disartan capsule was found to be 218.97 %. 3. The LS-SNEDDS formula (A18), showed extremely significant increase in Cpmax (1.74 fold) and AUC(0-{u221E}) (2.19 fold). 4. The desired enhancement of bioavailability of Valsartan from LS-SNEDDS was achieved via the observed shorter tmax as an indication of absorption rate and increase in the extent of drug absorption as indicated by the area under plasma concentration curve with a percentage relative bioavailability 218.97 %. Finally, LS-SNEDDS succeeded in enhancing Valsartan dissolution more significantly than liquid SNEDDS and S-SNEDDS due to the fact that LS- SNEDDS exhibited lager surface area exposed to the dissolution media. Therefore, the formulation of Valsartan as LS-SNEDDS could be a promising technique in improving its dissolution, bypassing first pass metabolism and thereby its bioavailability
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Sh.F (Browse shelf(Opens below)) Not for loan 01010110068022000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2015.Sh.F (Browse shelf(Opens below)) 68022.CD Not for loan 01020110068022000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

From the obtained results, it was possible to conclude the following: 1. After oral administration of Disartan capsule and LS-SNEDDS formula (A18) with dose equivalent to 30 mg Valsartan/ kg rat, the mean value of the plasma peak concentration (Cpmax) was found to be 8.26 ± 1.24 æg/ml and 14.38 ± 1.45 æg/ml respectively attained after tmax of 1.50 hr. and 0.50 hr. respectively. 2. The bioavailability of Valsartan from LS-SNEDDS relative to Disartan capsule was found to be 218.97 %. 3. The LS-SNEDDS formula (A18), showed extremely significant increase in Cpmax (1.74 fold) and AUC(0-{u221E}) (2.19 fold). 4. The desired enhancement of bioavailability of Valsartan from LS-SNEDDS was achieved via the observed shorter tmax as an indication of absorption rate and increase in the extent of drug absorption as indicated by the area under plasma concentration curve with a percentage relative bioavailability 218.97 %. Finally, LS-SNEDDS succeeded in enhancing Valsartan dissolution more significantly than liquid SNEDDS and S-SNEDDS due to the fact that LS- SNEDDS exhibited lager surface area exposed to the dissolution media. Therefore, the formulation of Valsartan as LS-SNEDDS could be a promising technique in improving its dissolution, bypassing first pass metabolism and thereby its bioavailability

Issued also as CD

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