header
Image from OpenLibrary

Possible treatment regimens against the hepatotoxic effect of some antitubercular drugs in rats / Mohamed Rizk Abdelkhalik Rizk ; Supervised Samy Abdelfattah Abdelazim , Rokaya Mahmoud Hussein , Ahmed Abdellatif Badr

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Rizk Abdelkhalik Rizk , 2015Description: 208 P. : charts , facsimiles ; 25cmOther title:
  • أنظمة علاج محتملة لتخفيف الآثار الكبدية الضارة لبعض الأدوية المستخدمة فى علاج مرضى السل فى الجرذان [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Aim: Tuberculosis is a dangerous disease and its death toll is increasing year by year. Intake of isoniazid and rifampicin might lead to fatal hepatorenal toxicity. The emerging field of stem cell therapy has raised great hope for improving the treatment of liver diseases. Results: The study revealed that serum liver enzymes activities, liver and kidney thiobarbituric acid reactive substance and nitric oxide levels, serum lipid profile and DNA fragmentation which exhibited by comet assay were significantly increased by isoniazid and rifampicin treatment associated with marked reduction of serum levels of albumin, total protein and albumin/globulin ratio, as well as liver and kidney glutathione levels and antioxidant enzymes activities, catalase and superoxide dismutase, as compared to normal controls. These results showed that N-acetyl cysteine, mesenchymal stem cells and white tea extract exerts their protective activity by different extents on liver and kidney by inhibiting the production of free radicals through induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant, glutathione, and returning back the tested parameters towards near the normal controls. Furthermore, liver and kidney functions were improved greatly by mesenchymal stem cells followed by N- acetyl cysteine and white tea extract, respectively
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Mo.P (Browse shelf(Opens below)) Not for loan 01010110068536000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.01.M.Sc.2015.Mo.P (Browse shelf(Opens below)) 68536.CD Not for loan 01020110068536000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Aim: Tuberculosis is a dangerous disease and its death toll is increasing year by year. Intake of isoniazid and rifampicin might lead to fatal hepatorenal toxicity. The emerging field of stem cell therapy has raised great hope for improving the treatment of liver diseases. Results: The study revealed that serum liver enzymes activities, liver and kidney thiobarbituric acid reactive substance and nitric oxide levels, serum lipid profile and DNA fragmentation which exhibited by comet assay were significantly increased by isoniazid and rifampicin treatment associated with marked reduction of serum levels of albumin, total protein and albumin/globulin ratio, as well as liver and kidney glutathione levels and antioxidant enzymes activities, catalase and superoxide dismutase, as compared to normal controls. These results showed that N-acetyl cysteine, mesenchymal stem cells and white tea extract exerts their protective activity by different extents on liver and kidney by inhibiting the production of free radicals through induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant, glutathione, and returning back the tested parameters towards near the normal controls. Furthermore, liver and kidney functions were improved greatly by mesenchymal stem cells followed by N- acetyl cysteine and white tea extract, respectively

Issued also as CD

There are no comments on this title.

to post a comment.