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Study on possible pharmacological effects of gliclazide alone or in combination with carbamazepine or alpha lipoic acid in experimentally induced diabetic neuropathy in rats / Mohamed Farouk Ahmed Abdelsalam ; Supervised Ezz-Eldin S. Eldenshary , Rania M. Abdelsalam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Farouk Ahmed Abdelsalam , 2015Description: 180 P. : charts ; 25cmOther title:
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: The present study aimed to evaluate the possible pharmacological effects of carbamazepine (CMB) and alpha lipoic acid (ALA) added to an antidiabetic agent, gliclazide (GZ), against experimentally induced diabetic neuropathy in rats. The study was divided into a pilot study and a main study. The pilot study was carried out to determine the time required to develop early diabetic neuropathy in STZ-induced diabetes in male rats. According to the results obtained from the pilot study, the main study was carried out to assess the possible treatment and prophylactic effects of CMB and ALA against the development of diabetic neuropathy after fourteen consecutive days of daily combined treatment with GZ. The assessments were accomplished by: 1- Monitoring behavioral responses to external thermal and mechanical stimuli. 2- Biochemical evaluation for carbohydrate metabolism by determining glucose serum levels and C-peptide, beside inflammatory biomarkers such as TNF alpha serum level and IL-10, oxidative stress biomarkers including serum nitric oxide (NO) level and MDA level, and high affinity insulin receptor (HAIR) and low affinity insulin receptor (LAIR) levels in hippocampus tissue
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Mo.S (Browse shelf(Opens below)) Not for loan 01010110068786000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2015.Mo.S (Browse shelf(Opens below)) 68786.CD Not for loan 01020110068786000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The present study aimed to evaluate the possible pharmacological effects of carbamazepine (CMB) and alpha lipoic acid (ALA) added to an antidiabetic agent, gliclazide (GZ), against experimentally induced diabetic neuropathy in rats. The study was divided into a pilot study and a main study. The pilot study was carried out to determine the time required to develop early diabetic neuropathy in STZ-induced diabetes in male rats. According to the results obtained from the pilot study, the main study was carried out to assess the possible treatment and prophylactic effects of CMB and ALA against the development of diabetic neuropathy after fourteen consecutive days of daily combined treatment with GZ. The assessments were accomplished by: 1- Monitoring behavioral responses to external thermal and mechanical stimuli. 2- Biochemical evaluation for carbohydrate metabolism by determining glucose serum levels and C-peptide, beside inflammatory biomarkers such as TNF alpha serum level and IL-10, oxidative stress biomarkers including serum nitric oxide (NO) level and MDA level, and high affinity insulin receptor (HAIR) and low affinity insulin receptor (LAIR) levels in hippocampus tissue

Issued also as CD

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