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Synthesis and biological evaluation of certain pyrazole derivatives / Ahmed Abbass Mohamed Abdelrahman ; Supervised Fatma Abdelfattah Ragab , Yassin Mohammed Nissan Soliman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Abbass Mohamed Abdelrahman , 2015Description: 284 P. : charts ; 25cmOther title:
  • تشييد و تقييم بيولوجى لبعض مركبات البيرازول [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: The present investigation deals with the semi-synthesis of certain 1,3,4- trisubstituted pyrazole derivatives derived from the natural furochromone khellin, to be screened for their in vivo anti-inflammatory activity and ulcerogenic liability hoping to obtain anti-inflammatory agents with high potency and lower side effects. Furthermore, PGE₂ and TNFÜ immunoassay were carried out to determine the percentage inhibition of these factors by the most active tested compounds. Docking study was conducted for the tested compounds on the active site of COX-2 enzyme to study the binding mode in the active site of the enzyme.The thesis consists of the following parts: 1.Introduction: In this section, literature review about the various biological and pharmacological activities especially the anti-inflammatory activity of pyrazole, pyrazoline, benzofuran and chalcone derivatives was presented. Also, different reported methods for the preparation of both pyrazole and pyrazoline nuclei were described
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Ah.S (Browse shelf(Opens below)) Not for loan 01010110069058000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2015.Ah.S (Browse shelf(Opens below)) 69058.CD Not for loan 01020110069058000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The present investigation deals with the semi-synthesis of certain 1,3,4- trisubstituted pyrazole derivatives derived from the natural furochromone khellin, to be screened for their in vivo anti-inflammatory activity and ulcerogenic liability hoping to obtain anti-inflammatory agents with high potency and lower side effects. Furthermore, PGE₂ and TNFÜ immunoassay were carried out to determine the percentage inhibition of these factors by the most active tested compounds. Docking study was conducted for the tested compounds on the active site of COX-2 enzyme to study the binding mode in the active site of the enzyme.The thesis consists of the following parts: 1.Introduction: In this section, literature review about the various biological and pharmacological activities especially the anti-inflammatory activity of pyrazole, pyrazoline, benzofuran and chalcone derivatives was presented. Also, different reported methods for the preparation of both pyrazole and pyrazoline nuclei were described

Issued also as CD

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