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Histological study on the possible protective effect of thyroid hormone on hepatic ischemia reperfusion injury in male rats / Hanan Abdalla Hassan Bastawy ; Supervised Mohammed Ahmed Abdalhafez , Mira Farouk Youssef , Dalia Ibrahim Ismail

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hanan Abdalla Hassan Bastawy , 2016Description: 121 P. : charts , facsimiles ; 25cmOther title:
  • دراسة هستولوجية وهستوكيميائية مناعية على التأثيرالوقائي المحتمل لهرمون الغدة الدرقية في الأصابة التى يسببها إنقطاع الدم ثم إعادة ضخه فى كبد الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology Summary: This study aimed at evaluating the effects of thyroid hormone (TH) on Ischemia reperfusion injury (IRI) in rat liver. Results: group II, showed no significant difference in the mean serum AST & ALT levels compared to the control rats. H&E sections revealed similar histological architecture of the liver parynchema as in control group. The statistical difference of the optical density of PAS and the mean area % of CD68 & iNOS immunoreactivity was non significant as compared with the control.. Group III showed significant increased in the mean serum AST & ALT levels compared to the control group. The H&E stained liver sections revealed disorganization, degeneration and necrosis of the hepatocytes with significant decrease in of the optical density of PAS and significant increase in the mean area % of CD68 & iNOS immunoreactivity compared to the control. Group VI showed significant decrease in the mean serum AST & ALT levels with decrease in the histological alterations caused by IRI. There was significance increase in the optical density of PAS reaction and significance decrease in the mean area % of CD68 and iNOS immunoreactivity when compared to the IRI group. Conclusion: TH have protective effect against hepatic IRI
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2016.Ha.H (Browse shelf(Opens below)) Not for loan 01010110069603000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2016.Ha.H (Browse shelf(Opens below)) 69603.CD Not for loan 01020110069603000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology

This study aimed at evaluating the effects of thyroid hormone (TH) on Ischemia reperfusion injury (IRI) in rat liver. Results: group II, showed no significant difference in the mean serum AST & ALT levels compared to the control rats. H&E sections revealed similar histological architecture of the liver parynchema as in control group. The statistical difference of the optical density of PAS and the mean area % of CD68 & iNOS immunoreactivity was non significant as compared with the control.. Group III showed significant increased in the mean serum AST & ALT levels compared to the control group. The H&E stained liver sections revealed disorganization, degeneration and necrosis of the hepatocytes with significant decrease in of the optical density of PAS and significant increase in the mean area % of CD68 & iNOS immunoreactivity compared to the control. Group VI showed significant decrease in the mean serum AST & ALT levels with decrease in the histological alterations caused by IRI. There was significance increase in the optical density of PAS reaction and significance decrease in the mean area % of CD68 and iNOS immunoreactivity when compared to the IRI group. Conclusion: TH have protective effect against hepatic IRI

Issued also as CD

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