Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This thesis consists of four parts including, the scientific study, literature review, references and summaries. Part {u04C0}: General introduction for locally acting drugs was presented. Part {u04C0}{u04C0}: Stability-indicating methods for determination of Clobetasol propionate in presence of its alkaline degradation products which includes five sections, Section A: Introduction and Literature Review for Clobetasol propionate were discussed, Section B: Forced degradation studies of Clobetasol propionate under alkaline stress condition were presented, Section C: it includes stability indicating TLC {u2013} densitometric method for the determination of Clobetasol propionate in presence of its alkaline degradation products, Section D: it includes first derivative of ratio spectrophotometric method for determination of Clobetasol propionate in presence of either its alkaline degradation products or Chlorocresol preservative present in its pharmaceutical formulation and Section E: ratio difference spectrophotometric method for determination of Clobetasol propionate in presence of its alkaline degradation products and Chlorocresol in its pharmaceutical formulation. Part {u04C0}{u04C0}{u04C0}: Determination of Benzydamine HCl and co-formulated compounds in its single or ternary mixture pharmaceutical formulations it includes three sections, Section A: includes introduction and literature review for Benzydamine HCl, Benzocaine and Cetalkonium chloride, Section B: includes potentiometric determination of Benzydamine HCl in its pharmaceutical formulations by Ion Selective Electrode and Section C: determination of Benzyadmine HCl, Benzocaine and Cetalkonium Chloride present in their spray form, which includes three subsections, Subsection (a): HPLC method for determination of Benzydamine HCl and Benzocaine, Subsection (b): TLC {u2013} densitometric method for determination of Benzydamine HCl and Benzocaine and Subsection (c): includes potentiometric determination of Cetalkonium Chloride by Ion Selective Electrode. Part VI: Determination of Cetrimide and co-formulated compounds Lidocaine HCl and Chlorhexidine Gluconate in their combined pharmaceutical formulations,

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