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Value of circulating GPC3 m RNA in detecting patient with hepatocellular carcinoma / Huda Ali Moustafa Karmani ; Supervised Nehad Ahmad Mosaad , Ashraf Omar Abdelaziz , Yassmin Taha Elshewey

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Huda Ali Moustafa Karmani , 2016Description: 133 P. ; 25cmOther title:
  • دور الحامض الريبوزومى الرسولى للجليبكان 3 فى الكشف عن المرضى المصابين بسرطان الكب [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Aim: Is to test the clinical performance of GLYPICAN 3 gene expression as a new and specific diagnostic molecular marker in hepatocellular carcinoma by real time PCR and its protein level in serum by ELISA. The serum GPC3 protein and GPC 3 m-RNA level were measured in 30 patients with HCC and 25 patients with cirrhotic liver disease (CLD) and 25 normal healthy control by RT-PCR and by ELISA. The median values of GPC3 m-RNA by RT-PCR in patients with HCC and with CLD and in control group were 2.68ng/mL, 0.843ng/mL and 0.2ng/ml respectively. We found There was no statistically significant elevation between the HCC group as compared to the CLD groups with (p = 0.407), while both groups were significantly higher than control group (p = 0.001). The median values of serum GPC3 protein by ELISA in patients with HCC and with CLD and in control group were 2.9ng/mL, 2.4ng/ml and 2.1ng/mL, respectively. We found that there was no statistically significant difference between the HCC and the CLD groups with (p = 0.488), while both groups were significantly higher than control group (p = 0.004). The median values of serum AFP by ELISA in patients with HCC and with CLD and in control groups were 171.0 ng/mL,13ng/ml and 2.3ng/mL, respectively. We found that. There was statistically significant difference between the HCC and the CLD groups with (p=0.000). And both of them were statistcally higher than the control group p = 0.000
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Hu.V (Browse shelf(Opens below)) Not for loan 01010110070242000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Hu.V (Browse shelf(Opens below)) 70242.CD Not for loan 01020110070242000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Aim: Is to test the clinical performance of GLYPICAN 3 gene expression as a new and specific diagnostic molecular marker in hepatocellular carcinoma by real time PCR and its protein level in serum by ELISA. The serum GPC3 protein and GPC 3 m-RNA level were measured in 30 patients with HCC and 25 patients with cirrhotic liver disease (CLD) and 25 normal healthy control by RT-PCR and by ELISA. The median values of GPC3 m-RNA by RT-PCR in patients with HCC and with CLD and in control group were 2.68ng/mL, 0.843ng/mL and 0.2ng/ml respectively. We found There was no statistically significant elevation between the HCC group as compared to the CLD groups with (p = 0.407), while both groups were significantly higher than control group (p = 0.001). The median values of serum GPC3 protein by ELISA in patients with HCC and with CLD and in control group were 2.9ng/mL, 2.4ng/ml and 2.1ng/mL, respectively. We found that there was no statistically significant difference between the HCC and the CLD groups with (p = 0.488), while both groups were significantly higher than control group (p = 0.004). The median values of serum AFP by ELISA in patients with HCC and with CLD and in control groups were 171.0 ng/mL,13ng/ml and 2.3ng/mL, respectively. We found that. There was statistically significant difference between the HCC and the CLD groups with (p=0.000). And both of them were statistcally higher than the control group p = 0.000

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