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Cognitive impairment in schizophrenia and genetic expression of GABA using human induced pluripotent stem cells / Dalia Khalifa Zayet ; Supervised Mahmoud Elbatrawi , Hala Gabr , Heba Fathy Eid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dalia Khalifa Zayet , 2016Description: 220 P. : facsimiles ; 25cmOther title:
  • الاضطراب المعرفى لمرضى الفصام و التعبير الجينى للجابا بإستخدام الخلايا الجذعية المتحوره المحفزة بواسطة الأنسان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry Summary: Neurotransmitters in general and GABA in particular are very important in normal cognition and the alteration of GABergic neurotransmission is accused to be sharing in the cognitive impairment in schizophrenia. GABA is the main inhibitory neurotransmitter in the brain. Its role in cognitive functioning is mediated through its effect on neurodevelopment, on fast synaptic transmission and also on gamma band synchronization. Exploring the molecular changes and cellular genetic expression of GaBergic genes is an essential step to know more about the real functioning of GABA in patients presenting with schizophrenia. Measure the genetic expression of (GAD65), GAD67, GABA beta2 and (mGLUR7) in patients presenting with schizophrenia and finding possible correlation with cognitive functions. Modeling of schizophrenia through human induced pleuripotent stem cells (hIPSc) through reprogramming of fibroblasts into hIPSc followed by neuronal differentiation. Real time PCR was used for measurement of genetic expression. Subtests of wechsler intelligence, trail A and B and rey ostrich test were used to assess cognitive functions
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.21.Ph.D.2016.Da.C (Browse shelf(Opens below)) Not for loan 01010110071040000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.21.Ph.D.2016.Da.C (Browse shelf(Opens below)) 71040.CD Not for loan 01020110071040000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Neurotransmitters in general and GABA in particular are very important in normal cognition and the alteration of GABergic neurotransmission is accused to be sharing in the cognitive impairment in schizophrenia. GABA is the main inhibitory neurotransmitter in the brain. Its role in cognitive functioning is mediated through its effect on neurodevelopment, on fast synaptic transmission and also on gamma band synchronization. Exploring the molecular changes and cellular genetic expression of GaBergic genes is an essential step to know more about the real functioning of GABA in patients presenting with schizophrenia. Measure the genetic expression of (GAD65), GAD67, GABA beta2 and (mGLUR7) in patients presenting with schizophrenia and finding possible correlation with cognitive functions. Modeling of schizophrenia through human induced pleuripotent stem cells (hIPSc) through reprogramming of fibroblasts into hIPSc followed by neuronal differentiation. Real time PCR was used for measurement of genetic expression. Subtests of wechsler intelligence, trail A and B and rey ostrich test were used to assess cognitive functions

Issued also as CD

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