header
Image from OpenLibrary

Influence of cyp3a5 gene polymorphism on cyclosporine dosage in kidney transplant recipients / Maha Sami Saad Almansi ; Supervised Dina Mohamed Elabd , Tarek Fayad , Amaal Abdo Abdelaal

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maha Sami Saad Almansi , 2016Description: 122 P. : charts ; 25cmOther title:
  • فى مرضى زراعة الكلى Cyclosporine على جرعات عقار CYP3A5 تأثير التعدد الشكلى لجين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Renal transplantation is currently the treatment of choice for end-stage renal disease (ESRD). The complications of the renal transplantation are rejection, nephrotoxicity of calcineurin inhibitors (CNI), and recurrence of native kidney disease. Cyclosporine (CsA) is a member of CNI family, which is widely used as a basic component of immunosuppressive regimens to prevent allograft rejection in solid organ transplantation. CYP3A4, and CYP3A5 are the main genes involved in the pharmacokinetics of CNI. Several single nucleotide polymorphisms were identified in these genes such as CYP3A5 (6986A > G). Aim of the work: To assess the impact of CYP3A5 (6986A > G) SNP on the dose and blood level of CsA among Egyptian renal transplant recipients after three months of transplantation. Subjects and methods: A total of 50 renal transplant recipients receiving CsA subjected to genotyping analysis of CYP3A5 (6986A > G) by Real-time PCR using the TaqMan SNP genotyping assay. The C0 and C2 of CsA were measured and their relationships with CYP3A5 genotypes were assessed
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ma.I (Browse shelf(Opens below)) Not for loan 01010110071039000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2016.Ma.I (Browse shelf(Opens below)) 71039.CD Not for loan 01020110071039000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Renal transplantation is currently the treatment of choice for end-stage renal disease (ESRD). The complications of the renal transplantation are rejection, nephrotoxicity of calcineurin inhibitors (CNI), and recurrence of native kidney disease. Cyclosporine (CsA) is a member of CNI family, which is widely used as a basic component of immunosuppressive regimens to prevent allograft rejection in solid organ transplantation. CYP3A4, and CYP3A5 are the main genes involved in the pharmacokinetics of CNI. Several single nucleotide polymorphisms were identified in these genes such as CYP3A5 (6986A > G). Aim of the work: To assess the impact of CYP3A5 (6986A > G) SNP on the dose and blood level of CsA among Egyptian renal transplant recipients after three months of transplantation. Subjects and methods: A total of 50 renal transplant recipients receiving CsA subjected to genotyping analysis of CYP3A5 (6986A > G) by Real-time PCR using the TaqMan SNP genotyping assay. The C0 and C2 of CsA were measured and their relationships with CYP3A5 genotypes were assessed

Issued also as CD

There are no comments on this title.

to post a comment.