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Biopharmaceutical study on selected improved carvedilol formulae in a certain dosage form / Doaa Mahmoud Abdelhamid Garhy ;supervised Mahmoud M. Ghorab , Howaida K. Ibrahim , Soha A. Ismail

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Mahmoud Abdelhamid Garhy , 2016Description: 182 P. : charts , facsimiles ; 25cmOther title:
  • دراسة بيوصيدلية لأشكال معدلة ومختارة من عقار الكارفيديلول فى شكل معين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Novel drug delivery dosage forms can provide improved benefits as enhancement in bioavailability, reduction of adverse effects and economic benefits. Elderly people may experience deterioration in their physiological and physical abilities which may lead to encountering difficulties in taking conventional dosage forms due to dysphagia. Carvedilol is Ü1/ non-cardioselective Ý-blocker that is used in the treatment of hypertension and many cardiovascular disorders. It is insoluble in water, intestinal fluids and gastric fluids that undergoes extensive first pass effect and has oral bioavailability of only 25-35%. Therefore, the aim of this thesis is to enhance the bioavailability through preparation of carvedilol nanoparticles to enhance dissolution and so absorption. Also, incorporation of the prepared nanoparticles in a gel form for buccal application to bypass the first pass effect and enhance the bioavailability
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2016.Do.B (Browse shelf(Opens below)) Not for loan 01010110071861000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2016.Do.B (Browse shelf(Opens below)) 71861 CD Not for loan 01020110071861000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Novel drug delivery dosage forms can provide improved benefits as enhancement in bioavailability, reduction of adverse effects and economic benefits. Elderly people may experience deterioration in their physiological and physical abilities which may lead to encountering difficulties in taking conventional dosage forms due to dysphagia. Carvedilol is Ü1/ non-cardioselective Ý-blocker that is used in the treatment of hypertension and many cardiovascular disorders. It is insoluble in water, intestinal fluids and gastric fluids that undergoes extensive first pass effect and has oral bioavailability of only 25-35%. Therefore, the aim of this thesis is to enhance the bioavailability through preparation of carvedilol nanoparticles to enhance dissolution and so absorption. Also, incorporation of the prepared nanoparticles in a gel form for buccal application to bypass the first pass effect and enhance the bioavailability

Issued also as CD

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