Epigenetics of the Epigenetics : Hypermethylation of microRNA let-7a-3 gene represses the primary and mature let-7a with an inverse correlation to IGF-II mRNA in HCV-induced hepatocellular carcinoma / Amr Adel Waly ; Supervised Ahmed Ihab Abdelaziz , Hand Mohamed Eltayebi

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Amr Adel Waly

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Material type: Text

TextLanguage: English Publication details: Cairo : Amr Adel Waly , 2013Description: 107 Leaves : charts , facsimiles ; 30cmSubject(s):

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Dissertation note: Thesis (M.Sc.) - Cairo University - Garman University - Faculty of Postgraduate Studies and Scientific Research- Department of Molecular Pharmacology Summary: Ongoing research has been focusing on the impact of the interplay between epigenetic mechanisms on malignant transformation. This work investigated the crosstalk between two of the epigenetic mechanisms: DNA methylation and microRNAs, in hepatocellular carcinoma (HCC). MicroRNA let-7a is a member of the arechetypal let-7a miRNA gene family. Owing to its know tumor suppressor activity, aberrant expression of microRNA let-7a was found to deregulate ~200 gene involved in cell proliferation, differentiation and adhesion.

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الثقاقات الاجنبية - الدور الثالث	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.34.M.Sc.2013.Am.E (Browse shelf(Opens below))	Not for loan	01010110072190000

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Thesis (M.Sc.) - Cairo University - Garman University - Faculty of Postgraduate Studies and Scientific Research- Department of Molecular Pharmacology

Ongoing research has been focusing on the impact of the interplay between epigenetic mechanisms on malignant transformation. This work investigated the crosstalk between two of the epigenetic mechanisms: DNA methylation and microRNAs, in hepatocellular carcinoma (HCC). MicroRNA let-7a is a member of the arechetypal let-7a miRNA gene family. Owing to its know tumor suppressor activity, aberrant expression of microRNA let-7a was found to deregulate ~200 gene involved in cell proliferation, differentiation and adhesion.

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