Mining ZINC database to discover potential phosphodiesterase 9 inhibitors using structure-based drug design approach / Engi Atef Mahmoud Hassaan ; Supervised Ashraf H. Abadi
Material type: TextLanguage: English Publication details: Cairo : Engi Atef Mahmoud Hassaan , 2014Description: 67 Leaves : chart , facsimiles ; 30cmOther title:- إستخدام قاعدة البيانات زينك لإستكشاف مركبات محتملة مهبطة للفسفودايستراز 9 من خلال التصميم المبني علي التركيب الجزيئي [Added title page title]
Item type | Current library | Home library | Call number | Status | Date due | Barcode | |
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Thesis | قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2014.En.M (Browse shelf(Opens below)) | Not for loan | 01010110072316000 |
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Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Phosphodiesterase enzymes are regulators of several cellular and non cellular funcation including cell cycle, metabolism, erectile dysfunction, and cognition. Their actions are mediated through controlling the concentrations of thrir substrates cAMP an cGMP. phosphodiesterase 9 is a cGMP spcsific phosphodiesterase highly exressed in maliganant tissues, tumors, CNS , and spongy tissues.
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