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Mining ZINC database to discover potential phosphodiesterase 9 inhibitors using structure-based drug design approach / Engi Atef Mahmoud Hassaan ; Supervised Ashraf H. Abadi

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Engi Atef Mahmoud Hassaan , 2014Description: 67 Leaves : chart , facsimiles ; 30cmOther title:
  • إستخدام قاعدة البيانات زينك لإستكشاف مركبات محتملة مهبطة للفسفودايستراز 9 من خلال التصميم المبني علي التركيب الجزيئي [Added title page title]
Subject(s): Dissertation note: Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Phosphodiesterase enzymes are regulators of several cellular and non cellular funcation including cell cycle, metabolism, erectile dysfunction, and cognition. Their actions are mediated through controlling the concentrations of thrir substrates cAMP an cGMP. phosphodiesterase 9 is a cGMP spcsific phosphodiesterase highly exressed in maliganant tissues, tumors, CNS , and spongy tissues.
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Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Phosphodiesterase enzymes are regulators of several cellular and non cellular funcation including cell cycle, metabolism, erectile dysfunction, and cognition. Their actions are mediated through controlling the concentrations of thrir substrates cAMP an cGMP. phosphodiesterase 9 is a cGMP spcsific phosphodiesterase highly exressed in maliganant tissues, tumors, CNS , and spongy tissues.

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