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Serum levels of cytokeratin 19 as a prognostic marker in patients with hepatocellular carcinoma on top of chronic HCV / Tarek Ahmed Moneer Abdelkhalek ; Supervised Maissa Elsaid Elraziky , Sahar Abdelaty Sharaf , Hanan Abdelhafez Hamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Tarek Ahmed Moneer Abdelkhalek Ismail , 2017Description: 140 P. : charts ; 25cmOther title:
  • المستوى المصلى للسيتوكيراتين ١٩ معامل تنبؤى لتطور المرض فى المرضى الذين يعانون من سرطان الكبد الأولى الناتج عن الالتهاب الكبدي المزمن الفيروسى سى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Background: HCC is the sixth most common cancer worldwide and the third most common cause of cancer death. HCC constitutes 70.48% of all liver tumors among Egyptians. HCC represents the main complication of cirrhosis. The cytokeratin 19 (CK19) belongs to a family of keratins, which are normally expressed in the lining of the gastro- enteropancreatic and hepatobiliary tracts. CK19 immunohistochemistry has been used successfully in thyroid tumors to recognize papillary carcinomas for some time. However, its use in the pancreas, liver, and gastrointestinal tract has only recently come to the fore. Aim: To evaluate the role of the serum level of CK19 in HCC patients as a prognostic marker. Methods: We measured the serum levels of (cytokeratin 19) in hepatocellular carcinoma patients who underwent appropriate therapeutic interventions for its hepatic focal lesions before interventions and then a month later and six months after appropriate intervention to discuss the possibility of use of this marker as predictive of progression of disease in those patients. Reslts: We demonstrated in this study that CK19 levels were significantly higher in patients with ablated focal lesions than in non ablated 1 and 6 months after intervention. Conclusion: Serum CK19 levels could be a simple, noninvasive way to predict tumor progression and evaluating treatment response and prognosis in patients with HCC amenable for intervention
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2017.Ta.S (Browse shelf(Opens below)) Not for loan 01010110073677000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.Ph.D.2017.Ta.S (Browse shelf(Opens below)) 73677.CD Not for loan 01020110073677000
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Cai01.11.33.Ph.D.2017.Mo.L Long term assessment of hepatic fibrosis after directly acting antiviral therapy for HCV recurrence post liver transplantation by liver stiffness measurement and ARFI / Cai01.11.33.Ph.D.2017.Sh.A Assessment of the presence of steatosis using Controlled Attenuation Parameter (CAP) and its effect on treatment outcome in Egyptian patients with chronic hepatitis C virus (HCV) treated with sofosbuvir based regimens / Cai01.11.33.Ph.D.2017.Sh.A Assessment of the presence of steatosis using Controlled Attenuation Parameter (CAP) and its effect on treatment outcome in Egyptian patients with chronic hepatitis C virus (HCV) treated with sofosbuvir based regimens / Cai01.11.33.Ph.D.2017.Ta.S Serum levels of cytokeratin 19 as a prognostic marker in patients with hepatocellular carcinoma on top of chronic HCV / Cai01.11.33.Ph.D.2017.Ta.S Serum levels of cytokeratin 19 as a prognostic marker in patients with hepatocellular carcinoma on top of chronic HCV / Cai01.11.33.Ph.D.2017.Wa.E Evaluation of the pattern of EPIYA motifs in the Helicobacter pylori CagA gene in Egyptian patients / Cai01.11.33.Ph.D.2017.Wa.E Evaluation of the pattern of EPIYA motifs in the Helicobacter pylori CagA gene in Egyptian patients /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Background: HCC is the sixth most common cancer worldwide and the third most common cause of cancer death. HCC constitutes 70.48% of all liver tumors among Egyptians. HCC represents the main complication of cirrhosis. The cytokeratin 19 (CK19) belongs to a family of keratins, which are normally expressed in the lining of the gastro- enteropancreatic and hepatobiliary tracts. CK19 immunohistochemistry has been used successfully in thyroid tumors to recognize papillary carcinomas for some time. However, its use in the pancreas, liver, and gastrointestinal tract has only recently come to the fore. Aim: To evaluate the role of the serum level of CK19 in HCC patients as a prognostic marker. Methods: We measured the serum levels of (cytokeratin 19) in hepatocellular carcinoma patients who underwent appropriate therapeutic interventions for its hepatic focal lesions before interventions and then a month later and six months after appropriate intervention to discuss the possibility of use of this marker as predictive of progression of disease in those patients. Reslts: We demonstrated in this study that CK19 levels were significantly higher in patients with ablated focal lesions than in non ablated 1 and 6 months after intervention. Conclusion: Serum CK19 levels could be a simple, noninvasive way to predict tumor progression and evaluating treatment response and prognosis in patients with HCC amenable for intervention

Issued also as CD

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