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Histological study on effect of curcumin versus aftamed on glucocorticoid induced skin atrophy and subsequent skin abrasions in male rats / Samia Hamdy Radwan Sayed ; Supervised Sohair Ahmed Fawzy Tawfiq , Nagwa Abdelwahab Ahmed , Mohamed Deiaa Eldin M. Elshafie

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samia Hamdy Radwan Sayed , 2018Description: 196 P. : charts , facsimiles ; 25cmOther title:
  • دراسة هستولوجية على تأثير الكركم مقارنة بالأفتاميد على ضمور الجلد المستحدث بالجلوكوكورتيكويد و سحجات الجلد اللاحقه له فى ذكور الفئران [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology Summary: This study aimed to evaluate the possible therapeutic effects of curcumin versus aftamed gel on glucocorticoid-induced skin atrophy, as well as on the subsequently induced abrasion wounds. Forty two adult male albino rats were divided into 4 groups: Group1 (Control group) of 6 rats. Group II (steroid-exposed Group) of 12 rats subdivided equally into two subgroups IIA (subjected to clobetasol propionate cream) and IIB (subsequently exposed to skin abrasion). Group III (curcumin-treated Group) of 12 rats were subdivided equally into two subgroups IIIA and IIIB. Group IV (Aftamed-treated group) of 12 rats subdivided equally into two subgroups IVA and IVB. Skin biopsies were taken from the dorsum of rats 12th days from the stoppage of clobetasol propionate application. Sections were stained with hematoxylin and eosin, Masson's trichrome and immunohistochemichal stain for PCNA and CK19. Epidermal thicknesses, mean area percent of collagen fibers and mean number of PCNA and CK19 immunopositive cells were measured. Steroid-exposed group showed thinning of epidermal and dermal layers with marked decrease in numbers of hair follicles and sebaceous glands with delay in wound healing. Increased epidermal thickness and reorganized dermal structural elements with increased PCNA and CK19 immunopositive cells are more obvious in curcumin than aftamed treated group. These findings suggest that topical application of curcumin had more improving effect on skin and its abrasions rather than aftamed gel
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2018.Sa.H (Browse shelf(Opens below)) Not for loan 01010110075481000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.16.Ph.D.2018.Sa.H (Browse shelf(Opens below)) 75481.CD Not for loan 01020110075481000
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Cai01.11.16.Ph.D.2018.Ro.C Comparative histological study on the protective effect of folinic acid versus fish oil on the growing bone of methotrexate-treated young rats / Cai01.11.16.Ph.D.2018.Sa.C Comparative study on the possible protective effect of oxytocin, dexmedetomidine and vitamin E on ischemia/reperfusion injury in rat skeletal muscle / Cai01.11.16.Ph.D.2018.Sa.C Comparative study on the possible protective effect of oxytocin, dexmedetomidine and vitamin E on ischemia/reperfusion injury in rat skeletal muscle / Cai01.11.16.Ph.D.2018.Sa.H Histological study on effect of curcumin versus aftamed on glucocorticoid induced skin atrophy and subsequent skin abrasions in male rats / Cai01.11.16.Ph.D.2018.Sa.H Histological study on effect of curcumin versus aftamed on glucocorticoid induced skin atrophy and subsequent skin abrasions in male rats / Cai01.11.16.Ph.D.2018.Ya.I Immunohistochemical study on the effect of adipose-derived stem cells versus clomiphen on treatment of experimental polycystic ovary in rats / Cai01.11.16.Ph.D.2018.Ya.I Immunohistochemical study on the effect of adipose-derived stem cells versus clomiphen on treatment of experimental polycystic ovary in rats /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology

This study aimed to evaluate the possible therapeutic effects of curcumin versus aftamed gel on glucocorticoid-induced skin atrophy, as well as on the subsequently induced abrasion wounds. Forty two adult male albino rats were divided into 4 groups: Group1 (Control group) of 6 rats. Group II (steroid-exposed Group) of 12 rats subdivided equally into two subgroups IIA (subjected to clobetasol propionate cream) and IIB (subsequently exposed to skin abrasion). Group III (curcumin-treated Group) of 12 rats were subdivided equally into two subgroups IIIA and IIIB. Group IV (Aftamed-treated group) of 12 rats subdivided equally into two subgroups IVA and IVB. Skin biopsies were taken from the dorsum of rats 12th days from the stoppage of clobetasol propionate application. Sections were stained with hematoxylin and eosin, Masson's trichrome and immunohistochemichal stain for PCNA and CK19. Epidermal thicknesses, mean area percent of collagen fibers and mean number of PCNA and CK19 immunopositive cells were measured. Steroid-exposed group showed thinning of epidermal and dermal layers with marked decrease in numbers of hair follicles and sebaceous glands with delay in wound healing. Increased epidermal thickness and reorganized dermal structural elements with increased PCNA and CK19 immunopositive cells are more obvious in curcumin than aftamed treated group. These findings suggest that topical application of curcumin had more improving effect on skin and its abrasions rather than aftamed gel

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