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Interleukin-10 gene polymorphism in Egyptian breast cancer patients / Shrouk Khalaf Elsayed Ahmed Ali ; Supervised Mona Mostafa Mohamed , Salwa Farouk Sabet , Mohamed Elsayed Elshinawi

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shrouk Khalaf Elsayed Ahmed Ali , 2017Description: 108 P. : charts ; 25cmOther title:
  • التنميط الجيني للانترلوكين 10 في مرضى سرطان الثدي المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Breast cancer isthe main cause of death in women worldwide. Indeed, genetic variation plays a vital role in carcinogenesis. Inflammatory breast cancer (IBC) is an aggressive and fatal form of breast cancer that is more prominent among young women and is characterized by a high number of axillary lymph node metastases at the time of presentation, poor prognosis and low survival rate(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014). Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, -1082A/G, -819T/C and -592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. As we targeted the most commonly three studied IL-10 promoter SNPs; rs1800896 ({u2212}1082A/G), rs1800871 ({u2212}819T/ C) and rs1800872 ({u2212}592A/C), GCC haplotype was found in association with over-increase in the risk of IBC. Also we found no association of IL-10 gene promoter polymorphisms in breast cancer progression (Stage, Grade, lymph node metastasis and distant metastasis). Moreover, we found increased expression of IL-10 gene in non-IBC and IBC than healthy control samples but a higher significant expression of IL-10 mRNA in IBC carcinoma tissues compared to non-IBC. GCC haplotype was the most correlated with increased expression of IL-10 than other estimated haplotype, and a markedly significant increase in IL-10 expression of GCC haplotype in IBC than non-IBC carcinoma tissue
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2017.Sh.I (Browse shelf(Opens below)) Not for loan 01010110075743000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2017.Sh.I (Browse shelf(Opens below)) 75743.CD Not for loan 01020110075743000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Breast cancer isthe main cause of death in women worldwide. Indeed, genetic variation plays a vital role in carcinogenesis. Inflammatory breast cancer (IBC) is an aggressive and fatal form of breast cancer that is more prominent among young women and is characterized by a high number of axillary lymph node metastases at the time of presentation, poor prognosis and low survival rate(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014)(Mohamed et al. 2008; Nouh et al. 2011; Victor et al. 2011; Mohamed 2012; Mohamed et al. 2014). Interleukin-10 is involved in carcinogenesis by supporting tumor escape from the immune response. The aim of this study was to assess the single nucleotide polymorphisms, -1082A/G, -819T/C and -592A/C, in interleukin-10 gene promoter in inflammatory breast cancer compared to non-inflammatory breast cancer and association of these polymorphisms with interleukin-10 gene expression. As we targeted the most commonly three studied IL-10 promoter SNPs; rs1800896 ({u2212}1082A/G), rs1800871 ({u2212}819T/ C) and rs1800872 ({u2212}592A/C), GCC haplotype was found in association with over-increase in the risk of IBC. Also we found no association of IL-10 gene promoter polymorphisms in breast cancer progression (Stage, Grade, lymph node metastasis and distant metastasis). Moreover, we found increased expression of IL-10 gene in non-IBC and IBC than healthy control samples but a higher significant expression of IL-10 mRNA in IBC carcinoma tissues compared to non-IBC. GCC haplotype was the most correlated with increased expression of IL-10 than other estimated haplotype, and a markedly significant increase in IL-10 expression of GCC haplotype in IBC than non-IBC carcinoma tissue

Issued also as CD

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