header
Image from OpenLibrary

Biological study on the effect of transforming growth factors on hepatic somatic stem cells propagated ex vivo / Mohammed Zaghloul Mohammed ; Supervised Motawa E. Elhussieni , Alaa Eldean Ismael A. Almottleb , Ahmad H. Elhabashy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Zaghloul Mohammed , 2018Description: 159 P. : charts , facsimiles ; 25cmOther title:
  • دراسة بيولوجية على تأثيرعوامل النموعلى الخلايا الجذعية الجسدية الكبدية المعزولة من مرضى سرطان الكبد [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Summary: Objective: This study had attempted to study the effect of TGF-Ý1 on hepatic somatic stem cells (HSSC) in vitro, since it could play an active role in the process of hepatocarcinogenesis and cancer metastases. We aimed to determine the HCC-specific molecular mechanisms mediating TGF-Ý1 dysregulation to a driver of tumor progression and characterize the molecular network between TGF-Ý1 and c-KIT signaling. Methods: Cancer stem cells were isolated from Hepatocellular carcinoma patients of different grades, and from age and sex matched healthy controls from safety margin and R N A isolation was done to get PCR product for mutations detection. Results: The results of this study showed that by using monoclonal characterization CD44 and CD90 for non-malignant liver tissue origin cells there are significant decreasing in CD40+CD90+ %by increasing TGF Ý1 concentration (P value <0.001). while for malignant liver tissue origin cells there are significant decreasing in CD40+CD90+ % only by using TGF Ý1 at concentration2.5 and 5 ng/dl P value <0.001
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2018.Mo.B (Browse shelf(Opens below)) Not for loan 01010110075789000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2018.Mo.B (Browse shelf(Opens below)) 75789.CD Not for loan 01020110075789000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Objective: This study had attempted to study the effect of TGF-Ý1 on hepatic somatic stem cells (HSSC) in vitro, since it could play an active role in the process of hepatocarcinogenesis and cancer metastases. We aimed to determine the HCC-specific molecular mechanisms mediating TGF-Ý1 dysregulation to a driver of tumor progression and characterize the molecular network between TGF-Ý1 and c-KIT signaling. Methods: Cancer stem cells were isolated from Hepatocellular carcinoma patients of different grades, and from age and sex matched healthy controls from safety margin and R N A isolation was done to get PCR product for mutations detection. Results: The results of this study showed that by using monoclonal characterization CD44 and CD90 for non-malignant liver tissue origin cells there are significant decreasing in CD40+CD90+ %by increasing TGF Ý1 concentration (P value <0.001). while for malignant liver tissue origin cells there are significant decreasing in CD40+CD90+ % only by using TGF Ý1 at concentration2.5 and 5 ng/dl P value <0.001

Issued also as CD

There are no comments on this title.

to post a comment.