Analysis of some drugs containing Amino group / Israa Mamdouh Nour ; Supervised Mostafa Abdelaty Shehata , Mohamed Refaat Elghobashy , Nagiba Yehia Mohamed

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This work is concerned with the quantitative determination of different drugs containing amino group namely, brinzolamide(BRZ), timolol(TML) and bumadiazone in their pure form, laboratory prepared mixtures and their pharmaceutical dosage forms in the presence of co-formulated excipients. In this study, different analytical techniques were developed, which include spectrophotometric, chemmometric and chromatographic methods for estimation of the drugs under study. Several experimental conditions were developed for optimization of the adopted methods.In part I; General introduction and literature review of brinzolamide (BRZ) and timolol (TML) were described. This part described also different analytical methods for the quantitative determination of BRZ and TML in their combination either in pure form or dosage form including spectrophotometry (ratio difference (RD), mean centering of ratio spectra (MCR), area under the curve (AUC) and Bivariate (BV)(, UV-Chemometry (PLS, PCR), TLC-Densitometry and HPLC. In part II; General introduction and literature review of bumadiazone (BDZ). Then different stability indicating methods were described for determination of bumadiazone in the presence of Its degradation product including spectrophotometric methods (ratio difference (RD), dual wave length, absorbance subtraction (AS) and absorbance ratio (AR)) and HPLC method

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