header
Local cover image
Local cover image
Image from OpenLibrary

Investigation of the metabolic profile of selected anticancer tyrosine kinase inhibitors by liquid chromatography mass spectroscopy / Mohamed Wagih Zeidan Attwa ; Supervised Sawsan Mohamed Mohamed Amer , Hany Wagih Darwish

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Wagih Zeidan Attwa , 2018Description: 170 P. : charts , facsimiles ; 25cmOther title:
  • تحديد و توصيف نواتج الأيض معمليا لبعض المركبات المضادة للسرطان بإستخدام الكروماتوجرافيا السائلة المتصلة بمقياس الطيف الكتلى [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: Incubation for the selected TKIs with RLMs alone or in the presence of KCN was done. Cyclic tertiary amine rings (N-methyl piperazine in PNT and MST, and N-methyl piperidine ring in VNT) were bioactivated and formed adducts with KCN. These reactive adducts may be responsible for the observed side effects of PNT and VNT in humans, and MST in animals and humans. Development of validated LC-MS/MS methods were done and applied to metabolic stability estimation. The low intrinsic clearance (3.91 and 3.0 mL/min/kg) with long in vitro t1/2 (40 min and 50 min.) of RLMs to metabolize VNT and MST, respectively suggested that VNT and MST are slowly cleared from the blood by the liver and thus considered as low extraction ratio drugs. The low intrinsic clearance of liver to metabolize VNT and MST is a specific character for the cited drugs not a general feature to similar TKIs as CLint for PNT was 15 mL/min/kg with short in vitro t1/2 of approximately 6 min. In vivo metabolism for the cited drugs were done. All the studied TKIs are partially excreted in the rat urine. Many oxidized metabolites were detected in rat urine for the cited drugs
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2018.Mo.I (Browse shelf(Opens below)) Not for loan 01010110076503000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.Ph.D.2018.Mo.I (Browse shelf(Opens below)) 76503.CD Not for loan 01020110076503000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

Incubation for the selected TKIs with RLMs alone or in the presence of KCN was done. Cyclic tertiary amine rings (N-methyl piperazine in PNT and MST, and N-methyl piperidine ring in VNT) were bioactivated and formed adducts with KCN. These reactive adducts may be responsible for the observed side effects of PNT and VNT in humans, and MST in animals and humans. Development of validated LC-MS/MS methods were done and applied to metabolic stability estimation. The low intrinsic clearance (3.91 and 3.0 mL/min/kg) with long in vitro t1/2 (40 min and 50 min.) of RLMs to metabolize VNT and MST, respectively suggested that VNT and MST are slowly cleared from the blood by the liver and thus considered as low extraction ratio drugs. The low intrinsic clearance of liver to metabolize VNT and MST is a specific character for the cited drugs not a general feature to similar TKIs as CLint for PNT was 15 mL/min/kg with short in vitro t1/2 of approximately 6 min. In vivo metabolism for the cited drugs were done. All the studied TKIs are partially excreted in the rat urine. Many oxidized metabolites were detected in rat urine for the cited drugs

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image