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Preparation of cellulosic nanomaterials from date palm stalks residues and their use in drug delivery systems / Wafaa Seleim Abou El-Seoud Seleim ; Supervised Magdy Sabaa Wadid Farag , Mohammad Lotfy Hassan

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Wafaa Seleim Abouelseoud Seleim , 2018Description: 174 P. : charts ; 25cmOther title:
  • تحضير مواد سليلوزية نانومترية من مخلفات سباط البلح و استخدامها في انظمة توصيل الدواء [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: This investigation aimed to use the cellulose nanocrystals (CNC) and chitosan nanoparticles (CHNP) for developing controlled drug delivery systems of the anti-hyperglycemic drug Repaglinide (RPG) and non-steroidal anti-inflammatory drug Ketoprofen (KP) via ionic gelation method. CNC were isolated from date palm stalks by sulfuric acid hydrolysis with dimensions of 86-237 nm in length and 5-7 nm in width. Chemical modification of CNC by oxidation to introduce carboxylic groups and by amine functionalization to introduce amino groups on their surface was also carried out for further controlling of RPG and KP release. The prepared systems containing CHNP and the different cellulose nanocrytals showed high entrapment efficiency of up to ~ 98% and 80% for RPG and KP, respectiely. Addition of the different cellulose nanocrystals to CHNP affected the release of the RPG and KP to different degrees depending on the loading and kind of the nanocrystals used (non- modified, carboxylated or aminated). Kinetic studies suggested that the release of RPG and KP from the different formulations were best fitted to Higuchi model
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2018.Wa.P (Browse shelf(Opens below)) Not for loan 01010110077059000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2018.Wa.P (Browse shelf(Opens below)) 77059.CD Not for loan 01020110077059000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry

This investigation aimed to use the cellulose nanocrystals (CNC) and chitosan nanoparticles (CHNP) for developing controlled drug delivery systems of the anti-hyperglycemic drug Repaglinide (RPG) and non-steroidal anti-inflammatory drug Ketoprofen (KP) via ionic gelation method. CNC were isolated from date palm stalks by sulfuric acid hydrolysis with dimensions of 86-237 nm in length and 5-7 nm in width. Chemical modification of CNC by oxidation to introduce carboxylic groups and by amine functionalization to introduce amino groups on their surface was also carried out for further controlling of RPG and KP release. The prepared systems containing CHNP and the different cellulose nanocrytals showed high entrapment efficiency of up to ~ 98% and 80% for RPG and KP, respectiely. Addition of the different cellulose nanocrystals to CHNP affected the release of the RPG and KP to different degrees depending on the loading and kind of the nanocrystals used (non- modified, carboxylated or aminated). Kinetic studies suggested that the release of RPG and KP from the different formulations were best fitted to Higuchi model

Issued also as CD

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