Assessment of the role of NOGO gene block in enhancing the neuro-regenerative effect of mesenchymal stem cells / Eman Ahmed Youssef ; Supervised Hala Gabr , Reham Afeefy , Nirmeen Adel
Material type:
- في تعزيز تأثير التجدد العصبي للخلايا الجذعية الوسيطة NOGO تقييم دور إسكات كتلة الجين [Added title page title]
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Item type | Current library | Home library | Call number | Copy number | Status | Barcode | |
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.07.Ph.D.2018.Em.A (Browse shelf(Opens below)) | Not for loan | 01010110077041000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.07.Ph.D.2018.Em.A (Browse shelf(Opens below)) | 77041.CD | Not for loan | 01020110077041000 |
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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Aim: Amyotrophic Lateral Sclerosis (ALS) is a fatal disease. Mesenchymal stem cells (MSCs) have a therapeutic potential in neuronal diseases, factors as NOGO A limit the axonal regeneration. In this study, gene silencing was used to suppress Nogo-A expression in MSCs, augmenting their neuro-regenerative role. Methods: MSCs were cultured from mice bone marrow then transfected with a plasmid coding for NOGO-A gene SiRNA, mouse models of motor neuron degeneration were created, therapeutic role of non-modified and plasmid transfected MSCs were studied and assessed clinically and histologically. Group 1 mice received no treatment. Group 2 received an IV injection of non modified MSCs and sacrificed 8 days (subgroup 2a) and 15 days (subgroup 2b) following treatment, Group 3 received an IV injection of transfected MSCs and were sacrificed 8 days (subgroup 3a) and 15 days (subgroup 3b) following treatment
Issued also as CD
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