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Role of syndecan-1 in modulating the interaction between monocytes and breast cancer stem cells / Noura Elhusseiny Bauomy Mohamed ; Supervised Mona Mostafa Mohamed , Noha Ahmed Mahana , Sherif Abdelaziz Ibrahim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Noura Elhusseiny Bauomy Mohamed , 2019Description: 81 P. : charts , facsimiles ; 25cmOther title:
  • دور السينديكان-١ فى تعديل التفاعل بين الخلايا احادية النواة و الخلايا الجذعية لسرطان الثدى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is characterized by a high infiltration of CD14+ monocytes. A growing body of evidence indicates that tumor-associated macrophages (TAMs) are classified into two major phenotypes, tumor inhibiting M1 and tumor promoting M2. The transmembrane heparan sulfate proteoglycan Syndecan-1 (Sdc-1) expression is induced in a variety of cell types during development and tumor progression and plays an essential role in regulation, recruitment and activation of monocytes in tumor microenvironment. We have recently shown that Sdc-1 is overexpressed in tumor tissue samples of IBC vs non-IBC. However, the role of Syndecan-1 in mediating macrophage polarization is still poorly studied. In the present study, we have employed siRNA approach to silence Syndecan-1 expression in the human breast cancer cell lines MDA-MB-231 (non-IBC) and SUM- 149 (IBC) cells
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.No.R (Browse shelf(Opens below)) Not for loan 01010110078716000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.No.R (Browse shelf(Opens below)) 78716.CD Not for loan 01020110078716000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is characterized by a high infiltration of CD14+ monocytes. A growing body of evidence indicates that tumor-associated macrophages (TAMs) are classified into two major phenotypes, tumor inhibiting M1 and tumor promoting M2. The transmembrane heparan sulfate proteoglycan Syndecan-1 (Sdc-1) expression is induced in a variety of cell types during development and tumor progression and plays an essential role in regulation, recruitment and activation of monocytes in tumor microenvironment. We have recently shown that Sdc-1 is overexpressed in tumor tissue samples of IBC vs non-IBC. However, the role of Syndecan-1 in mediating macrophage polarization is still poorly studied. In the present study, we have employed siRNA approach to silence Syndecan-1 expression in the human breast cancer cell lines MDA-MB-231 (non-IBC) and SUM- 149 (IBC) cells

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