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Efficacy of doxycycline in the treatment of early stages of mycosis fungoides : A randomized controlled trial / Hagar Elsayed Abdelghani Anter ; Supervised Mona R. E. Abdelhalim , Nesrin Samir Elkholy , Suzan Mohamed Shalaby

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hagar Elsayed Abdelghani Anter , 2019Description: 150 P. : charts , facsimiles ; 25cmOther title:
  • كفاءة عقار الدوكسيسيكلين فى علاج مرض الفطر الفطرانى - المراحل الأولية : تجربة عشوائية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerdogy Summary: Background: Mycosis fungoides (MF) is the most common type of primary cutaneous T cell lymphomas mostly resulting from defective T cell apoptosis. Doxycycline promoted apoptosis in different human malignant cell lines and in-vivo models. Objectives: To test for the therapeutic efficacy of doxycycline in comparison to PUVA in early stages of classic MF and its effect on the apoptosis of T lymphocytes. Methods: This randomized controlled trial (RCT) was conducted for 12 weeks. Thirty-six patients were randomized into either: doxycycline 200 mg daily (n=18) or PUVA (3 weekly sessions) (n=18). The primary outcome (therapeutic efficacy) was defined in terms of objective response rate (ORR) which was measured according to changes in the modified severity weighted assessment tool (mSWAT). Secondary outcomes included assessment of time to response (TTR) and changes in: the composite assessment of index lesion severity (CAILS), pruritus score, patient's satisfaction score (DLQI), serum Ý2 microglobulin level, serum LDH level, histopathology score and the immunohistochemical expression of CD3 and Bcl-2
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2019.Ha.E (Browse shelf(Opens below)) Not for loan 01010110078766000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.Ph.D.2019.Ha.E (Browse shelf(Opens below)) 78766.CD Not for loan 01020110078766000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerdogy

Background: Mycosis fungoides (MF) is the most common type of primary cutaneous T cell lymphomas mostly resulting from defective T cell apoptosis. Doxycycline promoted apoptosis in different human malignant cell lines and in-vivo models. Objectives: To test for the therapeutic efficacy of doxycycline in comparison to PUVA in early stages of classic MF and its effect on the apoptosis of T lymphocytes. Methods: This randomized controlled trial (RCT) was conducted for 12 weeks. Thirty-six patients were randomized into either: doxycycline 200 mg daily (n=18) or PUVA (3 weekly sessions) (n=18). The primary outcome (therapeutic efficacy) was defined in terms of objective response rate (ORR) which was measured according to changes in the modified severity weighted assessment tool (mSWAT). Secondary outcomes included assessment of time to response (TTR) and changes in: the composite assessment of index lesion severity (CAILS), pruritus score, patient's satisfaction score (DLQI), serum Ý2 microglobulin level, serum LDH level, histopathology score and the immunohistochemical expression of CD3 and Bcl-2

Issued also as CD

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