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Synthesis of some New pyrazolo[1,5-a]pyrimidine derivatives with expected biological activity / Ahmed Sabri Abdelmoety Gabr ; Supervised Hussein Fouad Zohdi , Nadia Hanafy Metwally

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Sabri Abdelmoety Gabr , 2019Description: 100 P. ; 25cmOther title:
  • 1,5-aتشييد بعض مشتقات البيرازولو يريميدين الجديدة و المتوقع لها نشاط بيولوجى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: The condensation of 2-(cyanomethyl)-7-(thiophen-2-yl)-5-(trifluoromethyl)pyrazolo- [1,5-a]pyrimidine-3-carbonitrile (3) with various aromatic aldehydes afforded crossponding substituted pyrazolo[1,5-a]pyrimidines 5a-j. The reaction of compound 3 with aryl diazonium chlorides in N,N-dimethylformamide furnished arylhydrazo compounds based pyrazolo[1,5-a]pyrimidine derivative. Also, reaction of compound 3 with 4-aryl azosalicylaldehydes afforded polyheterocyclic compounds based pyrazolo[1,5-a]pyrimidine derivative. The treatment of compound 3 with phenyl isothiocyanate, followed by addition of -haloesters or haloketones afforded polyheterocyclic compounds. Moreover, the enamines compound 3 react with each of hydrazine hydrate, guanidine hydrochloride to give the pyrazolo and pyrimidine derivatives. The structures of all the newly synthesized products were established by their elemental analyses, spectral data and possible mechanism has been postulated to account for their formation. The antiviral activity of some selected newly synthesized compounds was investigated
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2019.Ah.S (Browse shelf(Opens below)) Not for loan 01010110078963000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.M.Sc.2019.Ah.S (Browse shelf(Opens below)) 78963.CD Not for loan 01020110078963000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The condensation of 2-(cyanomethyl)-7-(thiophen-2-yl)-5-(trifluoromethyl)pyrazolo- [1,5-a]pyrimidine-3-carbonitrile (3) with various aromatic aldehydes afforded crossponding substituted pyrazolo[1,5-a]pyrimidines 5a-j. The reaction of compound 3 with aryl diazonium chlorides in N,N-dimethylformamide furnished arylhydrazo compounds based pyrazolo[1,5-a]pyrimidine derivative. Also, reaction of compound 3 with 4-aryl azosalicylaldehydes afforded polyheterocyclic compounds based pyrazolo[1,5-a]pyrimidine derivative. The treatment of compound 3 with phenyl isothiocyanate, followed by addition of -haloesters or haloketones afforded polyheterocyclic compounds. Moreover, the enamines compound 3 react with each of hydrazine hydrate, guanidine hydrochloride to give the pyrazolo and pyrimidine derivatives. The structures of all the newly synthesized products were established by their elemental analyses, spectral data and possible mechanism has been postulated to account for their formation. The antiviral activity of some selected newly synthesized compounds was investigated

Issued also as CD

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