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Biological evaluation of Interleukines 2, 12 and taurine combination against human hepatoma cells propagated ex-vivo / Tareq Hassan Muhmmad Jorob ; Supervised Motawa E. Elhouseini , Saad M. Elgendy , Abdelbary Prince

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Tareq Hassan Muhmmad Jorob , 2019Description: 97 P. : charts ; 25cmOther title:
  • التقييم البيولوجى للإنترلوكين 2, 12 و التورين المكمل للتأثير على خلايا أورام الكبد الخبيثة و التى تنمو خارج الجسم [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Summary: Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Therefore, it is important to search for agents that have a potential anticancer effect against HCC. The objective of the present study was to investigate the anti-cancer effects of interlekin-2 (IL-2), IL-12 and taurine in human hepatocellular carcinoma cells (Hep-G2). HepG2 cells was obtained from the National Cancer Institute and cultured in RPMI medium. Cells were classified into 6 groups, HepG2 cells without treatment as control group (group A), HepG2 cells treated with IL-2 (group B), HepG2 cells treated with IL-12 (group C), HepG2 cells treated with taurine (group D), HepG2 cells treated with IL-2 and IL-12 (group E) and HepG2 cells treated with IL-2, IL-12 and Taurine (group F). Viability of HepG2 cells was evaluated using MTT assay. Group B, E and F were significantly different from the control group with decreased viability in contrast to group C and D. LDH release assay was used to measure cytotoxicity of the previously mentioned natural agents. There was no significant difference between group D and the control group, while apparent cytotoxicity was observed in group B, C, E and F
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2019.Ta.B (Browse shelf(Opens below)) Not for loan 01010110079018000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2019.Ta.B (Browse shelf(Opens below)) 79018.CD Not for loan 01020110079018000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Therefore, it is important to search for agents that have a potential anticancer effect against HCC. The objective of the present study was to investigate the anti-cancer effects of interlekin-2 (IL-2), IL-12 and taurine in human hepatocellular carcinoma cells (Hep-G2). HepG2 cells was obtained from the National Cancer Institute and cultured in RPMI medium. Cells were classified into 6 groups, HepG2 cells without treatment as control group (group A), HepG2 cells treated with IL-2 (group B), HepG2 cells treated with IL-12 (group C), HepG2 cells treated with taurine (group D), HepG2 cells treated with IL-2 and IL-12 (group E) and HepG2 cells treated with IL-2, IL-12 and Taurine (group F). Viability of HepG2 cells was evaluated using MTT assay. Group B, E and F were significantly different from the control group with decreased viability in contrast to group C and D. LDH release assay was used to measure cytotoxicity of the previously mentioned natural agents. There was no significant difference between group D and the control group, while apparent cytotoxicity was observed in group B, C, E and F

Issued also as CD

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