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Prevalence and prognostic implication Of BCR/ABL fusion gene expression & JAK2 overexpression In Egyptian acute myeloid leukemia patients / Lamiaa Abdelfattah Fathalla Ahmed ; Supervised Basma Mostafa Mohammed Elgamal , Naglaa Mostafa Hassan Ahmed , Omnia Kamal Elgebaly

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Lamiaa Abdelfattah Fathalla Ahmed , 2019Description: 157 P. : charts , facsimiles ; 25cmOther title:
  • فى مرض سرطان الدم الميلودى الحاد فى المصريين و علاقتهم بالتنبؤ المرضى لديهم JAK2 و زيادة تعبير ال BCR/ABL دراسة نسبة انتشار جين ال [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: Background: Acute myeloid leukemia (AML) is a heterogenous disease with multiple established prognostic factors. JAK2 overexpression in AML was confirmed by many authors with an influence on the overall survival. Philadelphia positive AML (Ph+ AML) is a provisional entity in the recent WHO classification where discrimination from acute blastic crisis on top of chronic myeloid leukemia (CML) is still a challenge. Aims: to study JAK2 gene expression pattern in AML patients and its relation with other established prognostic variables and outcome parameters. Also, to determine the prevalence of the BCR-ABL fusion gene in AML cases with determination of the clinical and laboratory criteria of these cases. Methods: Prospective study on 175 AML patients treated at medical and pediatric oncology departments. Jak2 gene expression was evaluated by real time RT-PCR using taqman primer probe assay and BCR/ABL fusion was tested by conventional RT-PCR. All patients received current standard of care treatment for AML at NCI, Cairo University, Egypt
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2019.La.P (Browse shelf(Opens below)) Not for loan 01010110079188000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.03.Ph.D.2019.La.P (Browse shelf(Opens below)) 79188.CD Not for loan 01020110079188000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

Background: Acute myeloid leukemia (AML) is a heterogenous disease with multiple established prognostic factors. JAK2 overexpression in AML was confirmed by many authors with an influence on the overall survival. Philadelphia positive AML (Ph+ AML) is a provisional entity in the recent WHO classification where discrimination from acute blastic crisis on top of chronic myeloid leukemia (CML) is still a challenge. Aims: to study JAK2 gene expression pattern in AML patients and its relation with other established prognostic variables and outcome parameters. Also, to determine the prevalence of the BCR-ABL fusion gene in AML cases with determination of the clinical and laboratory criteria of these cases. Methods: Prospective study on 175 AML patients treated at medical and pediatric oncology departments. Jak2 gene expression was evaluated by real time RT-PCR using taqman primer probe assay and BCR/ABL fusion was tested by conventional RT-PCR. All patients received current standard of care treatment for AML at NCI, Cairo University, Egypt

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