Nanosized dosage forms as a tool for enhancing the solubility of a certain insoluble drug / Menna-t Allah Assem Metwally ; Supervised Dalia Mahmoud Ghorab , Omneya Abdelkader

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The emergence of combinatorial chemistry and high throughput screening in drug development programs has led to a generation of molecules with poor aqueous solubility and poor bioavailability profile. In recent years, newly research about active chemical entity had increased steadily in the number, but most of them are insoluble in water. More than 40% of the candidate drugs have poor water solubility. Topical delivery of drugs directly into the skin offers a targeted approach for the treatment of dermatological conditions and other localized disease states.Various strategies have been investigated in order to overcome the skin permeability barrier, which is the stratum corneum. Nanocarriers used to enhance dermal and transdermal delivery are colloids including liposomes,cubosomes, solid lipid nanoparticles, nanostructured lipid carriers, nanocrystals and finally lipid and polymer-based micellar solutions. Beclomethasone dipropionate is a highly potent glucocorticoid receptor agonist that interacts either directly with the DNA or indirectly by modulating specific transcription factors, resulting in the modulation of protein synthesis. It acts by inhibiting phospholipase A₂ resulting in the inhibition of arachidonic acid synthesis and controlling prostaglandins and leukotriene synthesis eventually, leading to anti-inflammatory, immunosuppressive and the antiproliferative effect. It is practically insoluble in water with poor dermal bioavailability

Issued also as CD