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Synthesis and biological evaluation of some new nitrogen heterocyclic compounds / Islam Zaki Abdelazeem Abutaleb ; Supervised Mohammed Kamal Abdelhameid , Khaled Omar Ahmed Mohamed , Ibrahim Elsayed Mohey Eldeen

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Islam Zaki Abdelazeem Abutaleb , 2019Description: 183 P. : charts ; 25cmOther title:
  • التشييد والتقييم البيولوجى لبعض المركبات النيتروجينية الغير متجانسة الجديدة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry Summary: A new series of diamide, imidazolone, 1,2,4-triazole and 1,2,4-triazinone derivatives have been designed, synthesized starting from N-benzoylglycine derivatives. Structures of the synthesized compounds have been deduced on the basis of their spectroscopic methods and elemental analyses data. The in vitroantitumor activity of the newly synthesized compounds were screenedagainstHepG2 and MCF-7 cell lines. Cell cycle analysis were carried out for some of the prepared compounds and demonstrated cell cycle arrest at G1 or G2/M phases of cell cycle.Additionally, the compounds produced a significant reduction in cellular microtubules for microtubule loss and potently inhibited the binding of [3H]colchicine to tubulin. Finally, some of the prepared compounds were proved to upregulate expression of proteins triggering apoptosis such as p53, Bax and decreased Bcl-2 overexpression as well as increased the expression of effector caspase-3/7.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.04.Ph.D.2019.Is.S (Browse shelf(Opens below)) Not for loan 01010110079498000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.04.Ph.D.2019.Is.S (Browse shelf(Opens below)) 79498.CD Not for loan 01020110079498000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry

A new series of diamide, imidazolone, 1,2,4-triazole and 1,2,4-triazinone derivatives have been designed, synthesized starting from N-benzoylglycine derivatives. Structures of the synthesized compounds have been deduced on the basis of their spectroscopic methods and elemental analyses data. The in vitroantitumor activity of the newly synthesized compounds were screenedagainstHepG2 and MCF-7 cell lines. Cell cycle analysis were carried out for some of the prepared compounds and demonstrated cell cycle arrest at G1 or G2/M phases of cell cycle.Additionally, the compounds produced a significant reduction in cellular microtubules for microtubule loss and potently inhibited the binding of [3H]colchicine to tubulin. Finally, some of the prepared compounds were proved to upregulate expression of proteins triggering apoptosis such as p53, Bax and decreased Bcl-2 overexpression as well as increased the expression of effector caspase-3/7.

Issued also as CD

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