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Design, synthesis and anticancer activity evaluation of new heterocyclic derivatives as PARP inhibitors / Ghada Fathy Hussein Elmasry ; Supervised Samir Mohamed Elmoghazy , Fadi Mohsen Awadallah , Enayat Ebrahim Aly

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ghada Fathy Hussein Elmasry , 2019Description: 110 P. : charts , facsimiles ; 25cmOther title:
  • تصميم و تشييد بعض المشتقات الحلقية الغير متجانسة كمضادات للسرطان من خلال تثبيط انزيم بارب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This work deals with the design and synthesis of some novel pyrido[2,3-d]pyridazinone derivatives; VIIIa-g, IXa,b, Xa-d and XIa-g as PARP-1 inhibitors. Molecular modeling techniques were used to support the design. The twenty newly synthesized compounds were evaluated for their ability to inhibit PARP-1. The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines. Computational ADME study was conducted to ensure that the most active compounds have proper pharmacokinetic and drug-likeness properties
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2019.Gh.D (Browse shelf(Opens below)) Not for loan 01010110079512000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2019.Gh.D (Browse shelf(Opens below)) 79512.CD Not for loan 01020110079512000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This work deals with the design and synthesis of some novel pyrido[2,3-d]pyridazinone derivatives; VIIIa-g, IXa,b, Xa-d and XIa-g as PARP-1 inhibitors. Molecular modeling techniques were used to support the design. The twenty newly synthesized compounds were evaluated for their ability to inhibit PARP-1. The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines. Computational ADME study was conducted to ensure that the most active compounds have proper pharmacokinetic and drug-likeness properties

Issued also as CD

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