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Synthesis and antitumor evaluation of heterocyclic compounds synthesized from B-diketone and cyanomethylene reagents / Bahaa Eldin Mohamed Bakr Mostafa Elzenary ; Supervised Raafat Milad Mohareb

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Bahaa Eldin Mohamed Bakr Mostafa Elzenary , 2019Description: 171 P. ; 25cmOther title:
  • تحضير و قياس مضاداث الأورام لمركبات حلقية غير متجاًنسة محضرة من بيتا ثنائى الكيتون و الميثيلين النشطة [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry Summary: The reaction of ethyl benzoyl acetate with malononitrile in an oil bath at 120{u00B0}C gave the condensation product 3. The latter compound underwent a series of heterocyclization to give thiophene, thiazole, pyridine and pyras derivatives. The structures of the synthesized products were established on the basis of analytical and spectral data. The antitumor evaluation of the newly synthesized products against the six cancer cell lines namely human gastric cancer (NUGC and HR), human colon cancer (DLDI), human liver cancer (HA22) and (HEPG2), human breast cancer (MCF), nasopharyngeal carcinoma (HONET) and normal fibroblast cells (w138) indicated that many compounds expressed high inhibition against the cancer cell lines. Compounds 3, 7a, 7e, 11b,13e, 13d, 16a,16b, 18a, 20a and 25b were the most cytotoxie compounds among the tested compouds
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2019.Ba.S (Browse shelf(Opens below)) Not for loan 01010110079979000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.10.Ph.D.2019.Ba.S (Browse shelf(Opens below)) 79979.CD Not for loan 01020110079979000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The reaction of ethyl benzoyl acetate with malononitrile in an oil bath at 120{u00B0}C gave the condensation product 3. The latter compound underwent a series of heterocyclization to give thiophene, thiazole, pyridine and pyras derivatives. The structures of the synthesized products were established on the basis of analytical and spectral data. The antitumor evaluation of the newly synthesized products against the six cancer cell lines namely human gastric cancer (NUGC and HR), human colon cancer (DLDI), human liver cancer (HA22) and (HEPG2), human breast cancer (MCF), nasopharyngeal carcinoma (HONET) and normal fibroblast cells (w138) indicated that many compounds expressed high inhibition against the cancer cell lines. Compounds 3, 7a, 7e, 11b,13e, 13d, 16a,16b, 18a, 20a and 25b were the most cytotoxie compounds among the tested compouds

Issued also as CD

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