header
Image from OpenLibrary

Evaluation of the genetic polymorphism in pre-microRNA-146a (rs2910164) and level of serum tumor necrosis factor alpha in patients with ischemic stroke and their effects on disease prognosis / Shaymaa Mohammed Abdelrahman Elasmer ; Supervised Manal Mohamed Kamal , Hanan Helmy Mohammed Elgendy , Radwa Marawan Abdelhalim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaymaa Mohammed Abdelrahman Elasmer , 2019Description: 125 P. : charts , facsimiles ; 25cmOther title:
  • ومعدل مصل عامل نخر الورم الفا بمرضى السكتة الدماغية وتاثيرهم على تطور المرض a لما قبل ميكروالحمض الريبوزى146 (rs2910164) تقييم ترابط التعدد الشكلى الجينى [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Inflammation plays a role in the pathogenesis of atherosclerosis and consequently ischemic stroke. Tumor necrosis factor-Ü (TNF-Ü) initiates a cascade of release of cytokines that increases the expression of adhesion molecules on the vascular endothelium. Moreover, single nucleotide polymorphism in Pre-miR-146a may contribute to susceptibility to ischemic stroke by altering mature miR-146a expression levels. Aim of the work: To investigate the association between the pre-miR-146a C> G (r2910164) polymorphism and serum TNF-Ü among group with ischemic stroke and in a group of unrelated volunteers. Subjects &Methods: This was a case control study on 75 cases with ischemic stroke and 75 sex matched control subjects with age range from 57-65 years. Demographic data and computerized tomography confirmation of ischemic stroke were taken from patients files. All samples were subjected to genomic DNA analysis for pre-miR-146a by real time PCR based method and TNF-Ü measurement by enzyme linked immunosobant assay. Results: The frequency of GG genotype within pre-miR-146a (rs2910164) in ischemic stroke cases was significantly different compared to the control subjects with P = 0.017, OR =3.07, 95%CI (1.2-7.7). A highly statistically significant increase in TNF-Ü level in ischemic stroke subjects when compared to the control group; P <0.001
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Sh.E (Browse shelf(Opens below)) Not for loan 01010110080140000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Sh.E (Browse shelf(Opens below)) 80140.CD Not for loan 01020110080140000
Browsing المكتبة المركزبة الجديدة - جامعة القاهرة shelves Close shelf browser (Hides shelf browser)
No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
No cover image available
Cai01.11.07.Ph.D.2019.Re.M Molecular analysis of 5 alpha reductase gene (SRD5A2) in 46, XY Egyptian patients with disorders of sex development / Cai01.11.07.Ph.D.2019.Sa.S Study of plasma circulating cell-free dna integrity as a biomarker for diagnosis of patients with HCV-related hepatocellular carcinoma / Cai01.11.07.Ph.D.2019.Sa.S Study of plasma circulating cell-free dna integrity as a biomarker for diagnosis of patients with HCV-related hepatocellular carcinoma / Cai01.11.07.Ph.D.2019.Sh.E Evaluation of the genetic polymorphism in pre-microRNA-146a (rs2910164) and level of serum tumor necrosis factor alpha in patients with ischemic stroke and their effects on disease prognosis / Cai01.11.07.Ph.D.2019.Sh.E Evaluation of the genetic polymorphism in pre-microRNA-146a (rs2910164) and level of serum tumor necrosis factor alpha in patients with ischemic stroke and their effects on disease prognosis / Cai01.11.07.Ph.D.2019.Sh.F The frequency of organic acidemias among Egyptian pediatric patients with suspected inborn errors of metabolism / Cai01.11.07.Ph.D.2019.Sh.F The frequency of organic acidemias among Egyptian pediatric patients with suspected inborn errors of metabolism /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Inflammation plays a role in the pathogenesis of atherosclerosis and consequently ischemic stroke. Tumor necrosis factor-Ü (TNF-Ü) initiates a cascade of release of cytokines that increases the expression of adhesion molecules on the vascular endothelium. Moreover, single nucleotide polymorphism in Pre-miR-146a may contribute to susceptibility to ischemic stroke by altering mature miR-146a expression levels. Aim of the work: To investigate the association between the pre-miR-146a C> G (r2910164) polymorphism and serum TNF-Ü among group with ischemic stroke and in a group of unrelated volunteers. Subjects &Methods: This was a case control study on 75 cases with ischemic stroke and 75 sex matched control subjects with age range from 57-65 years. Demographic data and computerized tomography confirmation of ischemic stroke were taken from patients files. All samples were subjected to genomic DNA analysis for pre-miR-146a by real time PCR based method and TNF-Ü measurement by enzyme linked immunosobant assay. Results: The frequency of GG genotype within pre-miR-146a (rs2910164) in ischemic stroke cases was significantly different compared to the control subjects with P = 0.017, OR =3.07, 95%CI (1.2-7.7). A highly statistically significant increase in TNF-Ü level in ischemic stroke subjects when compared to the control group; P <0.001

Issued also as CD

There are no comments on this title.

to post a comment.