header
Image from OpenLibrary

Association between superoxide dismutase 2 p.(Ala16Val) and superoxide dismutase 3 p.(Arg213Gly) polymorphisms and risk of neuropathy in Type 1 diabetic patients / Hala Ashraf Hosni Abdelaziz ; Supervised Heba Allah M. E. Sharaf Eldeen , Mona Mamdouh A. Hassan , Mai Hamed Mohamed Kamel

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hala Ashraf Hosni Abdelaziz , 2019Description: 111 P. : charts ; 25cmOther title:
  • و خطر الاعتلال العصبى فى مرضى السكرى من النوع الأول p.(Arg213Gly) 3و سوبرأوكسيد ديسميوتاز p.(Ala16Val) العلاقة بين تعدد الشكل الجينى لسوبرأوكسيد ديسميوتاز 2 [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Diabetic neuropathy (DN) is one of the debilitating microvascular complications of diabetes that is present in approximately 50% of patients. Marked increase in oxygen free radicals (OFR) results in oxidative stress that leads to development of DN. Antioxidant enzymes play a major role in protection against rapid onset and progression of DN, by reducing the excess OFR and peroxides. Mutations and variants in genes encoding such enzymes may therefore result in early onset and rapid progression of this complication. Aim: Investigating the association between Superoxide Dismutase 2 p.(Ala16Val) and superoxide dismutase 3 p. (Arg213Gly) gene variants and risk of neuropathy in Type 1 diabetic patients. Methods: Eighty type 1 diabetic patients were divided into two groups, forty patients have clinical DN (Group 1), and forty patients without neuropathy (Group 2). They were all tested for SOD2:p.(Ala16Val) and SOD3:p.(Arg213Gly) gene variants by Taqman Real Time PCR, and HbA1c was done to all patients
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Ha.A (Browse shelf(Opens below)) Not for loan 01010110080014000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2019.Ha.A (Browse shelf(Opens below)) 80014.CD Not for loan 01020110080014000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Diabetic neuropathy (DN) is one of the debilitating microvascular complications of diabetes that is present in approximately 50% of patients. Marked increase in oxygen free radicals (OFR) results in oxidative stress that leads to development of DN. Antioxidant enzymes play a major role in protection against rapid onset and progression of DN, by reducing the excess OFR and peroxides. Mutations and variants in genes encoding such enzymes may therefore result in early onset and rapid progression of this complication. Aim: Investigating the association between Superoxide Dismutase 2 p.(Ala16Val) and superoxide dismutase 3 p. (Arg213Gly) gene variants and risk of neuropathy in Type 1 diabetic patients. Methods: Eighty type 1 diabetic patients were divided into two groups, forty patients have clinical DN (Group 1), and forty patients without neuropathy (Group 2). They were all tested for SOD2:p.(Ala16Val) and SOD3:p.(Arg213Gly) gene variants by Taqman Real Time PCR, and HbA1c was done to all patients

Issued also as CD

There are no comments on this title.

to post a comment.