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Biochemical studies of hippocampal gene expression of brain toll like receptor in diabetic&derived neurotrophic factor rats exposed to chronic restraint stress : Effect of antidepressant drugs / Doaa Mohamed Hassan ; Supervised Ismail Abdelshafy Abdelhamid , Ahmed Ibrahim Amin , Samar Kamal Kassim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Mohamed Hassan , 2019Description: 156 P. : charts , facsimiles ; 25cmOther title:
  • دراسات كيميائية حيوية على التعبيرالجينى فى قرن امون لعامل التغذية العصبية المخية و مستقبل التول ليك فى الفئران المصابة بمرض السكر والمعرضة للضغط العصبى المزمن : تأثير مضادات الأكتئاب [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: This work investigates the alteration in gene expression of BDNF and TLR4 in the hippocampus of diabetic rats and non-diabetic maleWistar rats exposed to chronic restraint stress.Study included eight groups were used. fourgroups include: 1-Naïve rats, 2-non-diabetic CRS vehicle treated, 3-non-diabetic CRS fluoxetine treated&4- non-diabetic CRS imipramine treated; the same four groups with diabetic rats. Laboratory investigation were determined by using semi quantitative RT-PCR&ELISA. Diabetic rats & rats expose to CRS show significant decrease in gene expression & protein of BDNF with significant increase in in gene expression & protein of TLR4. It is concluded that BDNF & TLR genes has effective role with inflammatory state &stress and act in contrary manner and the preferable of fluoxetine over imipramine
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2019.Do.B (Browse shelf(Opens below)) Not for loan 01010110080268000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2019.Do.B (Browse shelf(Opens below)) 80268.CD Not for loan 01020110080268000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

This work investigates the alteration in gene expression of BDNF and TLR4 in the hippocampus of diabetic rats and non-diabetic maleWistar rats exposed to chronic restraint stress.Study included eight groups were used. fourgroups include: 1-Naïve rats, 2-non-diabetic CRS vehicle treated, 3-non-diabetic CRS fluoxetine treated&4- non-diabetic CRS imipramine treated; the same four groups with diabetic rats. Laboratory investigation were determined by using semi quantitative RT-PCR&ELISA. Diabetic rats & rats expose to CRS show significant decrease in gene expression & protein of BDNF with significant increase in in gene expression & protein of TLR4. It is concluded that BDNF & TLR genes has effective role with inflammatory state &stress and act in contrary manner and the preferable of fluoxetine over imipramine

Issued also as CD

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