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Assessment of the antitumor efficacy of annona muricata (Graviola) in breast and prostate human cancer cell lines / Razan Mohammed Hassan Mohammed ; Supervised Magda Mohamed Noshy , Hanan Ramadan Hamad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Razan Mohammed Hassan Mohammed , 2019Description: 77 P. : charts , facsimiles ; 25cmOther title:
  • تقييم الفاعليه المضادة للأورام لأنونا ميركاتا (غرافيولا) فى خطوط خلايا سرطان الثدى والبروستاتا البشرية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Background Graviola (Annona muricata) is a small tropical evergreen fruit tree that is widely grown in many tropical zones and used as traditional medicine to treat cancer and tumors. Graviola has been reported to be effective against various human tumors in vitro cultures. Although the underlying molecular mechanisms of its antitumor efficacy are not fully understood, it has been suggested that the induction of apoptosis in cancer cells may account for Graviola antitumor efficacy. Aim The present study aimed to investigate the antitumor efficacy of Graviola leaves extract and to explore its effect on the expression levels of certain apoptotic genes (P53, Bax and Bcl-2) in human breast cancer cell line (MCF-7) and human prostate cancer cell line (PC3). Since the DNA damage is likely to be the primary cause of apoptosis, this study also aimed to evaluate the potential of Graviola leaves extract to induce DNA damage in both human cancer cells. Materials and methods The anti-proliferative effect of the methanol extract of Graviola leaves was evaluated by neutral red uptake assay. Gene expression was assayed by using quantitative real time polymerase chain reaction (qRT-PCR) while DNA damage was estimated by using alkaline comet assay. Results The results revealed the cytotoxic potential of Graviola leaves extract against the studied human breast and prostate cancer cell lines
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ra.A (Browse shelf(Opens below)) Not for loan 01010110081645000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2019.Ra.A (Browse shelf(Opens below)) 81645.CD Not for loan 01020110081645000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Background Graviola (Annona muricata) is a small tropical evergreen fruit tree that is widely grown in many tropical zones and used as traditional medicine to treat cancer and tumors. Graviola has been reported to be effective against various human tumors in vitro cultures. Although the underlying molecular mechanisms of its antitumor efficacy are not fully understood, it has been suggested that the induction of apoptosis in cancer cells may account for Graviola antitumor efficacy. Aim The present study aimed to investigate the antitumor efficacy of Graviola leaves extract and to explore its effect on the expression levels of certain apoptotic genes (P53, Bax and Bcl-2) in human breast cancer cell line (MCF-7) and human prostate cancer cell line (PC3). Since the DNA damage is likely to be the primary cause of apoptosis, this study also aimed to evaluate the potential of Graviola leaves extract to induce DNA damage in both human cancer cells. Materials and methods The anti-proliferative effect of the methanol extract of Graviola leaves was evaluated by neutral red uptake assay. Gene expression was assayed by using quantitative real time polymerase chain reaction (qRT-PCR) while DNA damage was estimated by using alkaline comet assay. Results The results revealed the cytotoxic potential of Graviola leaves extract against the studied human breast and prostate cancer cell lines

Issued also as CD

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