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Development and validation of different analytical methods for determination of some drugs used for the treatment of GIT diseases / Mennatallah Ismail Ezz Eldin ; Supervised Marwa Ahmed Fouad , Ramzia Ismail Elbagary

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mennatallah Ismail Ezz Eldin , 2020Description: 282 P . : charts , facsmilies ; 25cmOther title:
  • تطوير و تقييم طرق تحليلية مختلفة لتقدير بعض الأدوية المستخدمة فى علاج أمراض الجهاز الهضمى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Different methods for the determination of some drugs used for the treatment of GIT diseases, in bulk, dosage forms and in rat liver homogenate have been introduced in this thesis. These drugs are aprepitant, fosaprepitant, ondansetron, palonosetron, tropisetron, omeprazole, pantoprazole and ranitidine. Chromatographic part includes UPLC determination of some mixtures namely a binary mixture of ondansetron and omeprazole in pharmaceutical dosage form, a ternary mixture of ondansetron, pantoprazole and ranitidine in two combined dosage forms. In addition, a validated UPLC method was developed for the determination of aprepitant and its prodrug fosaprepitant and applied to an in-vitro activation of prodrug fosaprepitant to the active drug aprepitant using liver S9 fraction. Spectroscopic part includes two quantitative nuclear magnetic resonance spectroscopic (QNMR) methods for the determination of ondansetron (OND) and omeprazole (OMP) in bulk drugs and theirpharmaceutical dosage forms
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2020.Me.D (Browse shelf(Opens below)) Not for loan 01010110081990000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2020.Me.D (Browse shelf(Opens below)) 81990.CD Not for loan 01020110081990000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Different methods for the determination of some drugs used for the treatment of GIT diseases, in bulk, dosage forms and in rat liver homogenate have been introduced in this thesis. These drugs are aprepitant, fosaprepitant, ondansetron, palonosetron, tropisetron, omeprazole, pantoprazole and ranitidine. Chromatographic part includes UPLC determination of some mixtures namely a binary mixture of ondansetron and omeprazole in pharmaceutical dosage form, a ternary mixture of ondansetron, pantoprazole and ranitidine in two combined dosage forms. In addition, a validated UPLC method was developed for the determination of aprepitant and its prodrug fosaprepitant and applied to an in-vitro activation of prodrug fosaprepitant to the active drug aprepitant using liver S9 fraction. Spectroscopic part includes two quantitative nuclear magnetic resonance spectroscopic (QNMR) methods for the determination of ondansetron (OND) and omeprazole (OMP) in bulk drugs and theirpharmaceutical dosage forms

Issued also as CD

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