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Design, synthesis and biological evaluation of some new barbituric acid derivatives with anticipated anticancer activity / Noura Sayed Hanafy Mahmoud ; Supervised Samir Mohamed Elmoghazy , Riham Francois George , Essam Eldin Abdelfattah Osman

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Noura Sayed Hanafy Mahmoud , 2020Description: 100 P. : charts , facsimiles ; 25cmOther title:
  • تصميم: تشييد وتقييم بيولوجى لبعض مشتقات حمض الباربيتيوريك الجديدة ذات نشاط متوقع كمضادات للسرطان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This work deals with the design and synthesis of some novel pyrimidinone derivatives; Va-e, VIa-e, VIIa-e, Xa-d, XIa-d and XIIa-d as PARP-1 inhibitors. Molecular modeling techniques were used to support the design.The twenty seven newly synthesized compounds were evaluated for their ability to inhibit PARP-1.The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines.The most active compounds against PARP1 in vitro were evaluated in the BRCA1 mutated breast cancer cell line MDA-MB-436
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2020.No.D (Browse shelf(Opens below)) Not for loan 01010110082257000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2020.No.D (Browse shelf(Opens below)) 82257.CD Not for loan 01020110082257000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This work deals with the design and synthesis of some novel pyrimidinone derivatives; Va-e, VIa-e, VIIa-e, Xa-d, XIa-d and XIIa-d as PARP-1 inhibitors. Molecular modeling techniques were used to support the design.The twenty seven newly synthesized compounds were evaluated for their ability to inhibit PARP-1.The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines.The most active compounds against PARP1 in vitro were evaluated in the BRCA1 mutated breast cancer cell line MDA-MB-436

Issued also as CD

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