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Novel diaryl urea based compounds : Mechanistic study and anticancer biological evaluation / Marwa Mohamed Mohamed Ahmed Sharaky ; Supervised Monira Mohamed Rageh , Samia Abdelsamieh Shouman , Khaled Abouzid Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Mohamed Mohamed Ahmed Sharaky , 2021Description: 2016 P . : charts,facsmilies ; 25cmOther title:
  • دراسه اليه و تقييم بيولوجى كمضادات للسرطان : مركبات ثنائى مشتقات الفنيل يوريا [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics Summary: Breast cancer is the most common cancer diagnosed in women. Tamoxifen (TAM) is the gold standard in therapy of estrogen receptor positive breast cancer (ER+ BC), however its efficacy is challenged by acquired resistance. Angiogenesis plays fundamental roles in TAM resistance where VEGFR-2 is a key player in this process. Thus, targeting of VEGFR-2 signaling pathway has been an attractive approach for BC therapy. In this study, we synthesized a new thieno[2,3-d]pyrimidine based urea derivative KM6, which exhibited potential antitumor activity in both TAM-sensitive MCF7 and TAM-resistant LCC2 BC cells. In addition to its antiangiogenic properties, KM6 retained the sensitivity of LCC2 via modulation of key proteins and enzymes of apoptosis and cell death (caspases 3,8,9, survivin, P53, BAX, BCL-2, LDH) and ROS. Moreover, KM6 modulated vital biological markers of inflammation (PGE2, COX2, IL-1Ý and IL6) and metastasis (MMP-2 and MMP-9). Thus, KM6 is a promising compound for ER+ and TAM-resistant BC with polypharmacological properties
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.Ph.D.2021.Ma.N (Browse shelf(Opens below)) Not for loan 01010110083306000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.Ph.D.2021.Ma.N (Browse shelf(Opens below)) 83306.CD Not for loan 01020110083306000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics

Breast cancer is the most common cancer diagnosed in women. Tamoxifen (TAM) is the gold standard in therapy of estrogen receptor positive breast cancer (ER+ BC), however its efficacy is challenged by acquired resistance. Angiogenesis plays fundamental roles in TAM resistance where VEGFR-2 is a key player in this process. Thus, targeting of VEGFR-2 signaling pathway has been an attractive approach for BC therapy. In this study, we synthesized a new thieno[2,3-d]pyrimidine based urea derivative KM6, which exhibited potential antitumor activity in both TAM-sensitive MCF7 and TAM-resistant LCC2 BC cells. In addition to its antiangiogenic properties, KM6 retained the sensitivity of LCC2 via modulation of key proteins and enzymes of apoptosis and cell death (caspases 3,8,9, survivin, P53, BAX, BCL-2, LDH) and ROS. Moreover, KM6 modulated vital biological markers of inflammation (PGE2, COX2, IL-1Ý and IL6) and metastasis (MMP-2 and MMP-9). Thus, KM6 is a promising compound for ER+ and TAM-resistant BC with polypharmacological properties

Issued also as CD

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