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The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin / Mohamed Hamdy Sayed Mansy ; Supervied Malak Mohamed Soliman , Rabab Tawfeek Mubarak

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Hamdy Sayed Mansy , 2020Description: 213 P. : charts , facsimiles ; 25cmOther title:
  • تأثير عامل نمو البشرة على الغدد اللعابية تحت الفكية فى الفئران البيضاء المزودة بعقار الدوكسوروبيسين [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology Summary: Epidermal growth factor (EGF) is a potent stimulant of proliferation and healing of the gastrointestinal tract. It is also acting as a cytoprotective agent that could stabilize cells against noxious agents. Doxorubicin (DXR) is widely used to treat different types of human neoplastic disease .Despite its high efficacy, the clinical application of doxorubicin was greatly restricted due to its multiple side effects. Since EGF exerts a potent growth and healing effect, it is supposed to play a role in the development and regeneration of salivary glands as well as oral mucosa. The present study was designed to investigate the effect of EGF injection on the cytotoxic effect of DXR induced in submandibular salivary gland of rats regarding the structure, ultrastructure, and immunohistochemical expression of VEGF and Ki-67. Sixty healthy adult male Albino rats, three months old and 200gm body weight were used in this study and were divided into three equal groups. Group I served as control group and the rats were received a single intraperitoneal injection of natural saline. In group II (DXR group), the rats received 20 mg/kg body weight DXR as a single intra peritoneal injection. Whereas , group III (DXR + EGF) was divided into two subgroups (A and B) .In group IIIA ,the rats received a single dose of DXR intraperitoneally (20 mg/kg body weight) and on the next day they were injected intraperitoneally with EGF in a daily dose of 10ug/kg body weight for 7 consecutive days. However, in group IIIB, the rats received the same intraperitoneal dose of DXR (20 mg/kg body weight) and 5 days later, they were injected with the same intraperitoneal dose of EGF (10ug/kg body weight) and for the same duration (7 consecutive days)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.12.Ph.D.2020.Mo.E (Browse shelf(Opens below)) Not for loan 01010110083339000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.12.Ph.D.2020.Mo.E (Browse shelf(Opens below)) 83339.CD Not for loan 01020110083339000
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Cai01.09.12.Ph.D.2019.Sh.E Evaluation of the protective effect of graviola on the deleterous effect of diabetes and insulin gene expression in submandibular salivary glands of albino rats : Animal study / Cai01.09.12.Ph.D.2020.Di.R The reparative potential of botox combined and uncombined with platelets rich plasma in treating induced osteoarthritis of temporomandibular joint in albino rats : An Animal study / Cai01.09.12.Ph.D.2020.Di.R The reparative potential of botox combined and uncombined with platelets rich plasma in treating induced osteoarthritis of temporomandibular joint in albino rats : An Animal study / Cai01.09.12.Ph.D.2020.Mo.E The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin / Cai01.09.12.Ph.D.2020.Mo.E The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin / Cai01.09.12.Ph.D.2020.No.B The bleaching potential of curcumin and strawberries (home remedies) versus carbamide peroxide (conventional home bleaching modality) : An in vitro study / Cai01.09.12.Ph.D.2020.No.B The bleaching potential of curcumin and strawberries (home remedies) versus carbamide peroxide (conventional home bleaching modality) : An in vitro study /

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology

Epidermal growth factor (EGF) is a potent stimulant of proliferation and healing of the gastrointestinal tract. It is also acting as a cytoprotective agent that could stabilize cells against noxious agents. Doxorubicin (DXR) is widely used to treat different types of human neoplastic disease .Despite its high efficacy, the clinical application of doxorubicin was greatly restricted due to its multiple side effects. Since EGF exerts a potent growth and healing effect, it is supposed to play a role in the development and regeneration of salivary glands as well as oral mucosa. The present study was designed to investigate the effect of EGF injection on the cytotoxic effect of DXR induced in submandibular salivary gland of rats regarding the structure, ultrastructure, and immunohistochemical expression of VEGF and Ki-67. Sixty healthy adult male Albino rats, three months old and 200gm body weight were used in this study and were divided into three equal groups. Group I served as control group and the rats were received a single intraperitoneal injection of natural saline. In group II (DXR group), the rats received 20 mg/kg body weight DXR as a single intra peritoneal injection. Whereas , group III (DXR + EGF) was divided into two subgroups (A and B) .In group IIIA ,the rats received a single dose of DXR intraperitoneally (20 mg/kg body weight) and on the next day they were injected intraperitoneally with EGF in a daily dose of 10ug/kg body weight for 7 consecutive days. However, in group IIIB, the rats received the same intraperitoneal dose of DXR (20 mg/kg body weight) and 5 days later, they were injected with the same intraperitoneal dose of EGF (10ug/kg body weight) and for the same duration (7 consecutive days)

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