Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Pediatrics

Introduction: More than 60% of children with systemic lupus erythematosus (SLE) develop lupus nephritis (LN). T cells play an important role in the pathogenesis of lupus nephritis (LN). The role of IL-2 in autoimmune and inflammatory diseases is known clear and can be studied from different points of view including diagnosis and treatment of these diseases. Soluble IL-2 receptor (sCD25) is released by activated lymphocytes and may be a measure of lymphocyte activation. Aim: To evaluate the role of urinary soluble CD25 (sCD25) as a noninvasive biomarker of lupus nephritis (LN) in pediatric SLE patients in a cross-sectional study.Methods: Urinary levels of soluble CD25 (sCD25) were assessed in 60 children with SLE (20 with active lupus nephritis ,20 with nonactive lupus nephritis and 20 SLE patients had never nephritis) and compared to 40 age and sex matched healthy controls. Results: Levels of urinary soluble CD25 (sCD25) were significantly higher in patients with active lupus nephritis (±45.8 ng/ml) than those inactive lupus nephritis (±29.4 ng/ml) (P<0.002). Also, levels of urinary soluble CD25 (sCD25) were higher in patients with inactive lupus nephritis (±29.4 ng/ml) than those without lupus nephritis (±16.2 ng/ml) (P<0.001) . Children with SLE had elevated urinary soluble CD25 (sCD25) (±16.2 ng/ml) as compared to controls (±9.9 ng/ml) (P<0.001). In our studied groups, urinary levels of soluble CD25 (sCD25) were correlated with increased serum creatinine and the quantitative and qualitative measures of proteinuria (P<0.001). Urinary of soluble CD25 (sCD25) was not significantly correlated with the complement levels and SLEDAI

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