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Utilization of a nanocarrier as a feasible tool for liver targeting of a certain drug / Shaimaa Ali Ali Radwan Moustafa ; Supervised Raguia Aly Shoukri , Aliaa Nabil Elmeshad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shaimaa Ali Ali Radwan Moustafa , 2021Description: 188 P . : charts , facsimiles ; 25cmOther title:
  • استخدام الحاملات متناهية الصغر كوسيلة ملائمة لتوصيل عقار معين إلى الكبد [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Gallic acid (GA) is characterized by its protective properties towards induced apoptosis in tumor cells, carbon tetrachloride induced liver injury and lung fibroblasts. It has the ability to hinder the proliferation of activated hepatic stellate cells (aHSCs) and control progression of liver fibrosis. However, the hydrophilic properties of GA hindered its entrapment in different vesicles formulations due to its fast partitioning with the surrounding aqueous media. Moreover, GA is poorly absorbed and rapidly metabolized leading to faster elimination and shorter peak plasma concentration and hence, diminished bioavailability. The present study aims to encapsulate GA into different nanocarrier systems for the passive and active targeting of GA to aHSCs for the effective treatment of liver fibrosis
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Sh.U (Browse shelf(Opens below)) Not for loan 01010110083698000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.Ph.D.2021.Sh.U (Browse shelf(Opens below)) 83698.CD Not for loan 01020110083698000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Gallic acid (GA) is characterized by its protective properties towards induced apoptosis in tumor cells, carbon tetrachloride induced liver injury and lung fibroblasts. It has the ability to hinder the proliferation of activated hepatic stellate cells (aHSCs) and control progression of liver fibrosis. However, the hydrophilic properties of GA hindered its entrapment in different vesicles formulations due to its fast partitioning with the surrounding aqueous media. Moreover, GA is poorly absorbed and rapidly metabolized leading to faster elimination and shorter peak plasma concentration and hence, diminished bioavailability. The present study aims to encapsulate GA into different nanocarrier systems for the passive and active targeting of GA to aHSCs for the effective treatment of liver fibrosis

Issued also as CD

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